NTRPX Meta System — Complete Formulations

Neuraldrink™ — Circadian Functional Beverages

Sol™

Daytime Hydration + Performance

Luna™

Nighttime Hydration + Recovery

Hydration is the foundation of biological performance — but water alone is insufficient. Neuraldrink™ delivers precision-formulated electrolyte beverages synchronized to circadian demands. Sol™ fuels daytime output with clean energy and cognitive support. Luna™ promotes deep sleep through thermoregulation while maintaining overnight hydration. Both integrate seamlessly with All Systems Go™ or function as powerful standalones.

Sol™ — Daytime Hydration + Performance

Timing

Morning through Early Afternoon

Primary Targets

Hydration, ATP, Dopaminergic

Philosophy

“Clean energy that sustains”

Form

Powder → 16-20 oz water

Complete Formulation

Sol™ Ingredient Matrix

Ingredient	Form	Dose	Primary Domain	Mechanism	Evidence Tier
Paraxanthine	enfinity®	100 mg	Adenosine	A2A antagonism; clean alertness	TIER 2
Creatine	Creapure® Monohydrate	2,500 mg	ATP Systems	Phosphocreatine buffering; dissolves well	TIER 1
L-Tyrosine	N-Acetyl-L-Tyrosine	300 mg	Dopaminergic	DA/NE precursor; stress resilience	TIER 1
Taurine	Pharmaceutical grade	1,000 mg	Cellular, Osmoregulation	Cellular hydration; antioxidant	TIER 1
Rhodiola Extract	3% salidroside	150 mg	HPA Axis	Adaptogenic; fatigue resistance	TIER 2
Electrolyte Complex	—	—	Hydration	Optimal cellular hydration	TIER 1
B-Vitamin Hydration Complex	Active forms	—	Energy, Methylation	Water-soluble; lost in sweat	TIER 1

Electrolyte Complex (per serving)

Electrolyte	Form	Dose	Rationale
Sodium	Sodium Citrate + Pink Himalayan	500 mg	Primary extracellular electrolyte; drives hydration
Potassium	Potassium Citrate	300 mg	Intracellular balance; muscle function
Magnesium	Magnesium Citrate	75 mg	Cofactor; often depleted; muscle relaxation
Chloride	From sodium chloride	200 mg	Fluid balance; gastric function
Calcium	Calcium Citrate	50 mg	Nerve transmission; muscle contraction

B-Vitamin Hydration Complex (within Sol™)

Vitamin	Form	Dose	Rationale
B1	Thiamine HCl	25 mg	Sweat loss replacement; energy
B2	Riboflavin-5’-Phosphate	10 mg	Energy metabolism
B3	Niacinamide	50 mg	NAD+ support
B5	D-Calcium Pantothenate	25 mg	CoA synthesis
B6	Pyridoxal-5’-Phosphate	10 mg	Amino acid metabolism
B12	Methylcobalamin	250 mcg	Energy; nerve function
Vitamin C	Ascorbic Acid	100 mg	Antioxidant; enhances absorption

Mechanism Integration

Usage Protocol

Optimal Use

Parameter	Recommendation	Rationale
Timing	Morning or early afternoon	Paraxanthine needs 6+ hours before sleep
Frequency	1-2 servings daily	Based on activity level and heat exposure
Mixing	16-20 oz cold water	Dissolve fully before drinking
Pairs with	Boost™ (morning) or Sustain™ (midday)	Complementary, not redundant

Activity-Based Dosing

Scenario	Sol™ Protocol
Office work	1 serving morning
Light exercise	1 serving pre-workout
Intense exercise / heat	1 serving pre, 1 serving during/post
Travel / dehydration	1-2 servings as needed

Flavor Options

Flavor	Notes
Citrus Sunrise	Orange, lemon, hint of ginger
Tropical Focus	Mango, pineapple, coconut
Berry Charge	Mixed berry, light tartness

Integration with All Systems Go™

Combination Protocol

Time	All Systems Go™	Neuraldrink™	Notes
6-7 AM	Boost™	—	Foundation morning stack
8-10 AM	—	Sol™	Hydration + extended energy
12-2 PM	Sustain™	—	Midday cognitive support
2-4 PM	—	Sol™ (optional)	If extended afternoon demands

Synergy Analysis

Combination	Effect	Caution
Sol™ + Boost™	Comprehensive morning activation	Total paraxanthine stays at 100mg (safe)
Sol™ + Sustain™	Total paraxanthine = 200mg	Maximum safe daily level; do not add ParaCaffeine +™
Sol™ + ParaCaffeine +™	200mg paraxanthine	Safe but watch timing; no more than 2PM

Paraxanthine Stacking: Sol™ contains 100mg paraxanthine. When combining with Sustain™ (100mg) or ParaCaffeine +™ (100mg), total daily paraxanthine should not exceed 300mg. Stay below 200mg for sleep-sensitive individuals.

Luna™ — Nighttime Hydration + Recovery

Timing

Evening (1-2 hours before bed)

Primary Targets

Hydration, Circadian, GABAergic

Philosophy

“Hydrate while you restore”

Form

Powder → 12-16 oz water

Complete Formulation

Luna™ Ingredient Matrix

Ingredient	Form	Dose	Primary Domain	Mechanism	Evidence Tier
Glycine	Pharmaceutical grade	3,000 mg	Circadian	Thermoregulation (-0.3°C core temp)	TIER 1
Magnesium	Magnesium Glycinate	200 mg elemental	GABAergic	GABA potentiation; relaxation; additional glycine	TIER 1
L-Theanine	Suntheanine®	150 mg	GABAergic	Alpha waves; calm without sedation	TIER 1
Taurine	Pharmaceutical grade	500 mg	GABAergic	GABA-A agonist; inhibitory tone	TIER 2
Apigenin	98% extract	25 mg	NAD+, GABAergic	CD38 inhibition; mild anxiolytic	TIER 2
Electrolyte Complex (Night)	—	—	Hydration	Overnight hydration; reduced sodium	TIER 1

Electrolyte Complex — Night (per serving)

Electrolyte	Form	Dose	Rationale
Sodium	Sodium Citrate	200 mg	Lower than Sol™; prevents nighttime thirst/urination
Potassium	Potassium Citrate	300 mg	Maintains intracellular balance
Magnesium	From Mag Glycinate above	(included)	Relaxation
Zinc	Zinc Picolinate	10 mg	Sleep regulation; immune overnight

Mechanism Integration

The Glycine-Thermoregulation Mechanism

Why 3g Glycine is Essential

Glycine at 3g triggers a specific physiological cascade:

Clinical Evidence	Finding	Reference
Bannai et al. 2012	3g glycine reduced core body temperature and improved subjective sleep quality	Sleep Biol Rhythms
Kawai et al. 2015	Glycine increased cutaneous blood flow, facilitating heat dissipation	Neuropsychopharmacology
Inagawa et al. 2006	3g glycine improved next-day alertness and reduced daytime fatigue	Sleep Biol Rhythms

Why This Matters: Most sleep supplements target sedation (GABA, melatonin). Luna™ targets the thermoregulatory pathway — the body’s natural sleep-onset mechanism. This produces deeper, more restorative sleep without morning grogginess or dependence.

Usage Protocol

Optimal Use

Parameter	Recommendation	Rationale
Timing	30-90 minutes before bed	Allows thermoregulation to initiate
Mixing	12-16 oz cool water	Smaller volume prevents nighttime urination
Temperature	Room temp or slightly cool	Hot liquid raises core temp (counterproductive)
Consistency	Nightly	Sleep architecture benefits compound

Flavor Options

Flavor	Notes
Lavender Calm	Light lavender, hint of vanilla
Chamomile Honey	Subtle sweetness, herbal notes
Unflavored	For those who prefer neutral; mixes into any beverage

Integration with All Systems Go™

Combination Protocol

Time	All Systems Go™	Neuraldrink™	Notes
6-8 PM	Dinner	—	Allow digestion
8-9 PM	—	Luna™	Begin thermoregulation
9-10 PM	Recover™	—	Complete sleep stack
10-11 PM	—	Sleep	Full protocol active

Synergy with Recover™

Ingredient	Recover™	Luna™	Combined Total	Notes
Glycine	3,000 mg	3,000 mg	6,000 mg	Safe; enhanced thermoregulation
Magnesium	244 mg	200 mg	444 mg	Optimal range; no excess
L-Theanine	200 mg	150 mg	350 mg	Enhanced alpha waves
Taurine	1,000 mg	500 mg	1,500 mg	Strong GABAergic tone
Apigenin	50 mg	25 mg	75 mg	Robust CD38 inhibition

Maximum Sleep Protocol: Recover™ + Luna™ together provides the most comprehensive sleep architecture support in the NTRPX system. The combination is safe and synergistic — use for periods of high recovery demand, jet lag, or sleep debt payoff.

ParaCaffeine +™ — Clean Stimulation

Timing

As Needed (before 2 PM)

Primary Targets

Adenosine, Dopaminergic

Philosophy

“Caffeine evolved — no jitters, no crash”

Form

Capsules (2)

Paraxanthine is caffeine’s primary active metabolite — the compound actually responsible for most of caffeine’s cognitive benefits. By supplementing paraxanthine directly, you bypass caffeine’s problematic metabolites (theobromine, theophylline) that cause anxiety, jitters, and sleep disruption. ParaCaffeine +™ delivers clean adenosine antagonism with synergistic cofactors for sustained, sleep-friendly alertness.

Why Paraxanthine > Caffeine

Caffeine Metabolism

Comparative Pharmacology

Property	Caffeine	Paraxanthine
A2A receptor affinity	1×	2.2×
Half-life	5-6 hours	3-4 hours
Anxiogenic metabolites	Yes (theophylline)	None
Sleep interference	High	Lower
Jitters/anxiety	Common	Rare
Tolerance development	Rapid	Slower
Crash	Common	Minimal

Clinical Evidence

Study	Design	N	Finding	Reference
Xing et al. 2021	RCT, DB, PC	11	Paraxanthine improved sustained attention and reaction time	Nutrients
Yoo et al. 2021	Acute pharmacology	—	Paraxanthine has higher A2A selectivity than caffeine	Psychopharmacology
Benowitz et al. 1995	Pharmacokinetic	10	Paraxanthine clearance faster than caffeine	Clin Pharmacol Ther

Complete Formulation

ParaCaffeine +™ Ingredient Matrix

Ingredient	Form	Dose	Primary Domain	Mechanism	Evidence Tier
Paraxanthine	enfinity®	100 mg	Adenosine	A2A antagonism; clean alertness	TIER 2
L-Theanine	Suntheanine®	200 mg	GABAergic	Smooths stimulation; alpha waves	TIER 1
CDP-Choline	Cognizin®	100 mg	Cholinergic	Sustains acetylcholine under stimulation	TIER 1
L-Tyrosine	N-Acetyl-L-Tyrosine	200 mg	Dopaminergic	Replenishes catecholamines	TIER 1
Theobromine	Cacao-derived	50 mg	Cardiovascular	Mild vasodilation; smooth energy curve	TIER 2
B6	Pyridoxal-5’-Phosphate	10 mg	Methylation	Neurotransmitter synthesis cofactor	TIER 1
B12	Methylcobalamin	250 mcg	Methylation	Energy; nerve function	TIER 1

Mechanism Integration

Why These Cofactors?

Cofactor	Rationale
L-Theanine	Proven synergy with xanthines; promotes alpha waves; eliminates jitteriness
CDP-Choline	Stimulants deplete acetylcholine; CDP-Choline prevents this
L-Tyrosine	Stimulants deplete catecholamines; tyrosine replenishes
Theobromine (low dose)	Extends energy curve without caffeine’s downsides
B6, B12	Neurotransmitter synthesis requires these cofactors

Usage Protocol

Optimal Use

Parameter	Recommendation	Rationale
Timing	Morning or early afternoon	Allow 6+ hours before sleep
Cutoff	2 PM (strict)	Even with shorter half-life, evening use affects sleep
Frequency	As needed, not daily	Prevents tolerance; maintains sensitivity
Maximum	2 servings (200mg paraxanthine)	Higher doses lose benefit/risk ratio

Comparison to Coffee

1 Cup Coffee (~95mg caffeine)	ParaCaffeine +™ (100mg paraxanthine)
Mixed metabolites	Pure active compound
Jitters common	Jitters rare
5-6 hour half-life	3-4 hour half-life
Sleep disruption likely	Sleep-compatible (if before 2 PM)
Crash common	Crash minimal
Acidic, GI issues	Neutral, well-tolerated

Integration with NTRPX

Combination	Total Paraxanthine	Recommendation
ParaCaffeine +™ alone	100 mg	Safe; ideal standalone
+ Sustain™	200 mg	Safe; do not add Sol™
+ Sol™	200 mg	Safe; do not add Sustain™
+ Sustain™ + Sol™	300 mg	Maximum; use rarely

Sprint™ — Acute Peak Performance

Timing

High-Demand Events Only

Primary Targets

Cholinergic MAX, Dopaminergic MAX

Philosophy

“Reserved for when you need peak output”

Form

Capsules (4-6)

Sprint™ is not for daily use. It is the high-performance formulation reserved for demanding cognitive events — presentations, exams, competitions, critical deadlines. Sprint™ provides maximum cholinergic drive via Alpha-GPC and Huperzine A, combined with dopaminergic surge from Mucuna pruriens (L-DOPA). This is the most aggressive nootropic stack in the NTRPX system, designed for occasional peak performance when the stakes are highest.

Sprint™ is for occasional use only (1-2× per week maximum). Daily use will lead to tolerance, receptor downregulation, and diminished efficacy. Reserve for genuinely high-demand situations.

Complete Formulation

Sprint™ Ingredient Matrix

Ingredient	Form	Dose	Primary Domain	Mechanism	Evidence Tier
Alpha-GPC	50%	600 mg (300 mg Alpha-GPC)	Cholinergic	Rapid, high-bioavailability choline; crosses BBB	TIER 2
Huperzine A	1% extract	200 mcg	Cholinergic	Acetylcholinesterase inhibitor; amplifies ACh	TIER 2
Mucuna pruriens	15% L-DOPA	500 mg (75 mg L-DOPA)	Dopaminergic	Direct dopamine precursor; bypasses rate-limitation	TIER 2
Caffeine Anhydrous	Pharmaceutical grade	100 mg	Adenosine	Broader receptor profile than paraxanthine; acute power	TIER 1
L-Theanine	Suntheanine®	200 mg	GABAergic	Balances stimulation; prevents overshoot	TIER 1
CDP-Choline	Cognizin®	250 mg	Cholinergic	Additional choline; membrane support	TIER 1
Phosphatidylserine	Sharp-PS®	100 mg	Neuroprotection	Membrane; cortisol modulation under pressure	TIER 1
Lion’s Mane	Fruiting body 8:1	500 mg	Neuroprotection	NGF support; neuroplasticity	TIER 2
TTFD	Thiamine derivative	50 mg	Mitochondrial	BBB-penetrant B1; cognitive energy	TIER 3
B6	Pyridoxal-5’-Phosphate	25 mg	Dopaminergic	DOPA decarboxylase cofactor	TIER 1
B12	Methylcobalamin	1,000 mcg	Methylation	Elevated for acute demand	TIER 1

Mechanism Integration

Why Caffeine Instead of Paraxanthine?

For Sprint™ specifically, caffeine is preferred:

Factor	Rationale
Broader receptor profile	Caffeine hits A1 and A2A; more complete adenosine blockade
Faster onset	Caffeine peaks faster for acute demands
Occasional use context	Sleep disruption less relevant for single-use scenarios
Synergy with L-DOPA	Traditional pairing with demonstrated effects

Evidence Base

Key Clinical Evidence

Ingredient	Study	Design	N	Dose	Finding	Reference
Alpha-GPC	Parker et al. 2015	RCT, DB, PC	48	600mg	↑ Lower body force production	J Int Soc Sports Nutr
Alpha-GPC	Bellar et al. 2015	RCT	13	600mg	↑ Isometric strength	J Int Soc Sports Nutr
Huperzine A	Sun et al. 1999	RCT, DB, PC	103	200mcg BID	↑ Memory in AD patients	Zhongguo Yao Li Xue Bao
Mucuna	Katzenschlager et al. 2004	RCT	8 PD patients	30g (contains L-DOPA)	Comparable to L-DOPA/carbidopa	J Neurol Neurosurg Psychiatry
Caffeine + L-Theanine	Haskell et al. 2008	RCT, DB, PC	48	150mg + 250mg	↑ Attention, task switching	Biol Psychol

Usage Protocol

When to Use Sprint™

✅ Appropriate	❌ Not Appropriate
Major presentation	Daily productivity
Final exam	Regular work tasks
Competition day	Catching up on sleep debt
Critical negotiation	Social events
Job interview	Routine exercise
Creative deadline	Ongoing projects

Protocol

Parameter	Recommendation	Rationale
Timing	60-90 minutes before peak demand	Allows full onset
Frequency	1-2× per week MAXIMUM	Prevents tolerance
Cycling	2 weeks on, 1 week off if using weekly	Maintains efficacy
Sleep	Do not use after 12 PM	Caffeine + L-DOPA will disrupt sleep
Food	Light meal or empty stomach	Heavy food delays absorption

What to Expect

Timeframe	Effects
30-60 min	Onset of alertness, focus sharpening
60-180 min	Peak performance window
3-5 hours	Gradual return to baseline
Post-event	May feel mentally tired (normal; used resources)

Do NOT combine Sprint™ with All Systems Go™ Boost on the same day. Sprint™ replaces Boost™ for that day. Combining creates excessive stimulation and cholinergic load.

Safety Considerations

Contraindications

Condition	Recommendation
Cardiovascular disease	Avoid (caffeine, stimulation)
Anxiety disorders	Avoid (may exacerbate)
Pregnancy/nursing	Avoid
MAO inhibitor medications	Contraindicated (L-DOPA interaction)
Parkinson’s medications	Consult physician (L-DOPA overlap)
Glaucoma	Caution (cholinergic effects)

Side Effect Management

Potential Side Effect	Cause	Management
Overstimulation	Caffeine + L-DOPA	Reduce dose; add more L-theanine
Headache	Cholinergic excess	Ensure hydration; reduce next dose
GI upset	L-DOPA	Take with light food
Insomnia	Too late in day	Strict AM use only

Complete Meta System Summary

Total System Architecture

All Products at a Glance

Usage Scenarios

Protocol Options

Goal	Protocol	Products
Basic optimization	Foundation only	All Systems Go™ (Boost → Sustain → Recover)
Enhanced hydration	Foundation + Beverages	All Systems Go™ + Sol™ + Luna™
Caffeine replacement	Entry point	ParaCaffeine +™
Sleep focus	Evening stack	Recover™ + Luna™
Maximum daily	Complete circadian	Boost → Sol → Sustain → Luna → Recover
High-demand event	Acute performance	Sprint™ (replaces Boost that day)

Sample Weekly Schedule

Day	Morning	Midday	Evening	Notes
Monday	Boost + Sol	Sustain	Recover + Luna	Full protocol
Tuesday	Boost	Sustain + ParaCaffeine+	Recover	Extra afternoon energy
Wednesday	Boost + Sol	Sustain	Recover + Luna	Full protocol
Thursday	Sprint	(ride effect)	Recover + Luna	Major presentation
Friday	Boost	Sustain	Recover	Standard day
Saturday	Sol only	—	Luna	Light weekend
Sunday	—	—	Luna	Rest day

Quality Specifications

Ingredient Sourcing Standards

Category	Standard	Verification
Branded ingredients	Use specified brands (Cognizin®, Suntheanine®, etc.)	CoA required
Generic ingredients	≥98% purity pharmaceutical grade	Third-party testing
Botanical extracts	Standardized to active compounds	HPLC verification
Heavy metals	USP <232>/<233> limits	ICP-MS testing
Microbial	USP <2021> standards	Batch testing
Stability	24-month shelf life	Accelerated stability data

Manufacturing Standards

Parameter	Requirement
Facility	cGMP-certified
Testing	Identity, potency, purity each batch
Encapsulation	Vegetarian capsules (HPMC)
Powder mixing	V-blender with validated homogeneity
Packaging	UV-protective bottles; desiccant included

Document Control

Version	Date	Author	Changes
1.0	2026-01-24	NTRPX R&D	Complete Meta System formulations

NTRPX Meta System™ Complete: Seven integrated products spanning foundation daily support (All Systems Go™), circadian beverages (Neuraldrink™), clean stimulation (ParaCaffeine +™), and acute performance (Sprint™). Every ingredient, dose, and timing decision made with full awareness of the complete system. Use individually for targeted benefits, or combine for complete biological optimization across all 12 domains of human performance.

Start Here

Method

Systems

Formulations

Ingredient Manual

Evaluations

Community

​Neuraldrink™ — Circadian Functional Beverages

Sol™

Luna™

​Sol™ — Daytime Hydration + Performance

Timing

Primary Targets

Philosophy

Form

​Sol™ Ingredient Matrix

​Electrolyte Complex (per serving)

​B-Vitamin Hydration Complex (within Sol™)

​Mechanism Integration

​Optimal Use

​Activity-Based Dosing

​Flavor Options

​Combination Protocol

​Synergy Analysis

​Luna™ — Nighttime Hydration + Recovery

Timing

Primary Targets

Philosophy

Form

​Luna™ Ingredient Matrix

​Electrolyte Complex — Night (per serving)

​Mechanism Integration

​Why 3g Glycine is Essential

​Optimal Use

​Flavor Options

​Combination Protocol

​Synergy with Recover™

​ParaCaffeine +™ — Clean Stimulation

Timing

Primary Targets

Philosophy

Form

​Caffeine Metabolism

​Comparative Pharmacology

​Clinical Evidence

​ParaCaffeine +™ Ingredient Matrix

​Mechanism Integration

​Why These Cofactors?

​Optimal Use

​Comparison to Coffee

​Integration with NTRPX

​Sprint™ — Acute Peak Performance

Timing

Primary Targets

Philosophy

Form

​Sprint™ Ingredient Matrix

​Mechanism Integration

​Why Caffeine Instead of Paraxanthine?

​Key Clinical Evidence

​When to Use Sprint™

​Protocol

​What to Expect

​Contraindications

​Side Effect Management

​Complete Meta System Summary

​All Products at a Glance

​Protocol Options

​Sample Weekly Schedule

​Ingredient Sourcing Standards

​Manufacturing Standards

​Document Control

Neuraldrink™ — Circadian Functional Beverages

Sol™ — Daytime Hydration + Performance

Sol™ Ingredient Matrix

Electrolyte Complex (per serving)

B-Vitamin Hydration Complex (within Sol™)

Mechanism Integration

Optimal Use

Activity-Based Dosing

Flavor Options

Combination Protocol

Synergy Analysis

Luna™ — Nighttime Hydration + Recovery

Luna™ Ingredient Matrix

Electrolyte Complex — Night (per serving)

Mechanism Integration

Why 3g Glycine is Essential

Optimal Use

Flavor Options

Combination Protocol

Synergy with Recover™

ParaCaffeine +™ — Clean Stimulation

Caffeine Metabolism

Comparative Pharmacology

Clinical Evidence

ParaCaffeine +™ Ingredient Matrix

Mechanism Integration

Why These Cofactors?

Optimal Use

Comparison to Coffee

Integration with NTRPX

Sprint™ — Acute Peak Performance

Sprint™ Ingredient Matrix

Mechanism Integration

Why Caffeine Instead of Paraxanthine?

Key Clinical Evidence

When to Use Sprint™

Protocol

What to Expect

Contraindications

Side Effect Management

Complete Meta System Summary

All Products at a Glance

Protocol Options

Sample Weekly Schedule

Ingredient Sourcing Standards

Manufacturing Standards

Document Control