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NTRPX Systems — Complete Formulations v3

Version 3 Corrections:
  • Removed paraxanthine from Neuraldrink™ Sol (ParaCaffeine +™ is the optional stimulant add-on)
  • All salidroside now ≥98% pure precision-fermented, capsules only (bitter)
  • Complete taste profile verification for all Neuraldrink™ ingredients
  • Added physiological melatonin micro-dose (0.3mg) to Recover™
  • Huperzine A changed to ≥98% synthetic pure form
  • Removed non-acute ingredients from Sprint™ (PS, Lion’s Mane)
  • Sodium sources changed to pharmaceutical grade (removed Pink Himalayan)
  • Added complete glucose:fructose carbohydrate system to Neuraldrink™
  • Verified All Systems Go™ independence from Neuraldrink™

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All Systems Go™ — Foundation System

The complete daily protocol. Standalone viability — does NOT depend on Neuraldrink™ for optimization.

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☀️ Boost™ — Morning Activation

Timing

6:00 - 10:00 AM

With Food

Light breakfast

Format

Capsules (6-8 capsules)

Philosophy

“Wake up sharp, not wired”

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Boost™ Complete Formulation

IngredientFormDoseDomainNotes
CDP-CholineCognizin®300 mgCholinergicPharmaceutical-grade citicoline
L-TyrosineN-Acetyl-L-Tyrosine (NALT)500 mgDopaminergicImproved stability vs free form
CreatineCreapure® Monohydrate2,500 mgATP SystemsCombined with Sustain = 5g/day
PQQBioPQQ®20 mgMitochondrialClinically validated dose
CoQ10Kaneka Ubiquinol100 mgMitochondrialReduced form; 8× absorption
Salidroside≥98% Precision Fermented15 mgHPA AxisPureRosea™; NOT Rhodiola extract
Lion’s ManeDual Extract (Fruiting Body + Mycelium)500 mgNeuroprotectionStandardized to hericenones + erinacines

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Boost™ B-Complex (Active Forms Only)

VitaminFormDoseRationale
B1Benfotiamine150 mgFat-soluble; AGE inhibition; peripheral nerves
B1TTFD (Sulbutiamine)50 mgCNS-penetrant thiamine; crosses BBB
B2Riboflavin-5’-Phosphate (R5P)15 mgActive coenzyme; supports B6/B9 activation
B3Nicotinamide100 mgNAD+ precursor; no flush
B5D-Calcium Pantothenate50 mgCoA synthesis
B6Pyridoxal-5’-Phosphate (P5P)15 mgONLY safe form — pyridoxine neurotoxic
B7D-Biotin300 mcgKeep <1000mcg (lab interference)
B9L-5-MTHF (Quatrefolic®)400 mcgActive folate; bypasses MTHFR
B12Methylcobalamin500 mcgCytoplasmic coenzyme
B12Adenosylcobalamin250 mcgMitochondrial coenzyme

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🌤️ Sustain™ — Daytime Performance

Timing

10:00 AM - 2:00 PM

With Food

With lunch

Format

Capsules (6-8 capsules)

Philosophy

“All-day cognitive endurance”

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Sustain™ Complete Formulation

IngredientFormDoseDomainNotes
CDP-CholineCognizin®250 mgCholinergicContinued ACh support
CreatineCreapure® Monohydrate2,500 mgATP SystemsCombined with Boost = 5g/day
PhosphatidylserineSharp-PS® (sunflower)100 mgNeuroprotectionChronic membrane support
L-TheanineSuntheanine®100 mgGABAergicAlpha waves; calm focus
Bacopa monnieriBaCognize® 45% bacosides300 mgMemoryChronic nootropic
AshwagandhaKSM-66®300 mgHPA AxisCortisol modulation
Saffronaffron® 3.5% lepticrosalides28 mgSerotonergicMood support
DHALife’s DHA® (algal)250 mgStructuralNeuronal membrane
EPAAlgal125 mgCardiovascularAnti-inflammatory

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Sustain™ B-Complex Continuation

VitaminFormDose
B1Benfotiamine100 mg
B2R5P10 mg
B5Calcium Pantothenate50 mg
B6P5P10 mg
B12Adenosylcobalamin250 mcg

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🌙 Recover™ — Evening Recovery

Timing

30-60 min before bed

With/Without

Light or empty stomach

Format

Capsules + Powder (glycine)

Philosophy

“Sleep deep, wake restored”

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Recover™ Complete Formulation

IngredientFormDoseDomainNotes
GlycinePharmaceutical grade3,000 mgCircadianCore temp ↓0.3°C — non-negotiable dose
Magnesium L-ThreonateMagtein®144 mg (elem.)GABAergicBrain-penetrant Mg
Magnesium GlycinateChelated100 mg (elem.)GABAergicGABA potentiation + glycine
L-TheanineSuntheanine®200 mgGABAergicAlpha waves; relaxation
Apigenin≥98% extract50 mgNAD+CD38 inhibition; anxiolytic
TaurinePharmaceutical grade1,000 mgGABAergicGABA-A agonist
NRNiagen®300 mgNAD+Overnight NAD+ restoration
MelatoninPharmaceutical grade0.3 mgCircadianPhysiological dose (MIT research)
ZincZinc Picolinate15 mgRepairSleep regulation; immune

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Recover™ Evening B-Vitamins

VitaminFormDoseRationale
B6P5P10 mgGABA synthesis cofactor
B9L-5-MTHF400 mcgOvernight methylation
B12Methylcobalamin250 mcgNo sleep interference

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MIT Research on Physiological Melatonin Dosing

Dr. Richard Wurtman’s research at MIT established critical findings:
DoseEffectSustainability
0.3 mgPhysiological; restores normal nocturnal levels✅ Does not suppress endogenous production
3.0 mgSupraphysiological (10×); LESS effective❌ May cause tolerance, hypothermia
Key findings:
  • 0.3 mg raises plasma melatonin to within the normal nocturnal range (113 ± 13.5 pg/ml)
  • Higher doses (3mg+) are actually less effective for treating insomnia
  • Low doses don’t cause “hangover effects”
  • One-month treatment maintained efficacy without tolerance in primate studies
Why this works with Glycine:
  • Glycine → thermoregulatory sleep onset (peripheral mechanism)
  • Melatonin 0.3mg → gentle circadian signal (central mechanism)
  • Complementary, non-redundant pathways

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All Systems Go™ Daily Totals

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Summary: What You Get Per Day

CategoryBoost™Sustain™Recover™Daily Total
Creatine2,500 mg2,500 mg—5,000 mg ✓
CDP-Choline300 mg250 mg—550 mg ✓
Magnesium——244 mg244 mg
DHA + EPA—375 mg—375 mg
All B-vitaminsDistributedDistributedDistributedComplete ✓

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All Systems Go™ Independence Verification

All Systems Go™ is COMPLETE without Neuraldrink™:
  • Full creatine dosing (5g/day) ✓
  • Full choline support (550mg/day) ✓
  • Full B-complex (active forms) ✓
  • Full omega-3 (DHA + EPA) ✓
  • Full sleep support (glycine, magnesium, NR, melatonin) ✓
  • Full adaptogens (salidroside, ashwagandha, bacopa) ✓
Neuraldrink™ ADDS:
  • Optimized hydration + electrolytes
  • Brain glucose fuel (cognitive facilitation)
  • Additional glycine (Luna) for enhanced sleep

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Neuraldrink™ — Circadian Functional Beverages

Precision-formulated hydration drinks — taste-optimized for daily enjoyment.

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Neuraldrink™ Taste Profile Requirements

Ingredient Placement Rules for Drink Mixes:The following ingredients are EXCLUDED from Neuraldrink™ due to taste/solubility:
IngredientIssueAppropriate Product
SalidrosideBitterBoost™, Sprint™ (capsules)
PQQRed-orange color; bitterBoost™ (capsules)
Alpha-GPCFishy tasteSprint™ (capsules)
Huperzine AExtremely bitterSprint™ (capsules)
PhosphatidylserineFat-soluble; doesn’t dissolveSustain™ (capsules)
BacopaBitterSustain™ (capsules)
AshwagandhaEarthy/bitterSustain™ (capsules)
CreatineSandy texture; incomplete dissolutionBoost™/Sustain™ (capsules)
Lion’s ManeEarthy tasteBoost™ (capsules)
Neuraldrink™ ingredients must be: ✓ Water-soluble (complete dissolution) ✓ Neutral or sweet taste (or easily masked) ✓ Stable in solution ✓ Color-compatible with citrus drink

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☀️ Sol™ — Daytime Hydration + Energy

Timing

Morning through Early Afternoon

Serving

Mix in 16-20 oz water

Flavor

Citrus (Lemon-Lime / Orange)

Philosophy

“Clean energy that sustains”

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Sol™ Complete Formulation

NO PARAXANTHINE — ParaCaffeine +™ is the optional stimulant add-on for those who want it. Sol™ is pure hydration + brain fuel + NO support.

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Carbohydrate System (Brain Fuel)

IngredientAmountFunctionTaste
D-Glucose Monohydrate15 gImmediate brain fuel; cognitive facilitationSweet ✓
Fructose8 gSustained energy; liver glycogenVery sweet ✓
Glucose:Fructose Ratio: 65:35 (optimized for brain + sustained energy)
Total Sugars: 23g per serving

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Active Ingredients

IngredientFormDoseDomainTaste Profile
L-CitrullineFree form3,000 mgCardiovascularSlightly tart ✓ (citrus-compatible)
CordycepsCS-4 Water Extract1,000 mgMitochondrialMild; easily masked ✓
TaurinePharmaceutical grade1,000 mgCellularSlightly sweet ✓
L-TyrosineFree form300 mgDopaminergicNeutral ✓

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Electrolyte Complex (Pharmaceutical Grade)

ElectrolyteFormDoseNotes
SodiumSodium Citrate (USP)500 mgCitrate provides alkalinity
SodiumSodium Chloride (USP)500 mgNaCl for chloride
PotassiumPotassium Citrate (USP)500 mgIntracellular balance
MagnesiumMagnesium Citrate75 mg (elem.)Tart; citrus-compatible ✓
CalciumCalcium Citrate100 mg (elem.)Neutral ✓
Chloride(from NaCl above)~300 mgFluid balance
Total Sodium: 1,000 mg (from citrate + chloride sources)

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B-Vitamin Hydration Complex

VitaminFormDoseTaste
B1Thiamine HCl2 mgMild ✓
B2R5P2 mgSlight yellow; mild ✓
B3Niacinamide25 mgMild; no flush ✓
B5Calcium Pantothenate15 mgMild ✓
B6P5P5 mgMild ✓
B12Methylcobalamin250 mcgTasteless ✓
Vitamin CAscorbic Acid100 mgTart; citrus-compatible ✓
ChromiumChromium Picolinate100 mcgTasteless ✓

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Sol™ is NOT a Stimulant Drink

Design Philosophy:
  • Sol™ = foundational hydration + brain fuel + nitric oxide support
  • ParaCaffeine +™ = optional clean stimulant add-on
  • Users should be able to hydrate WITHOUT stimulation
Use Cases:
  • Afternoon hydration (after 2PM cutoff for stimulants)
  • Hydration during/after exercise
  • Users who don’t want stimulants
  • Cycling off stimulants
If you want stimulation: Add ParaCaffeine +™ to your protocol

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Why Pharmaceutical Grade Sodium, NOT Pink Himalayan

Research findings on Pink Himalayan Salt:
ConcernEvidence
Lead contamination2020 Australian study: one sample exceeded maximum contaminant level (>2 mg/kg)
Microplastics2023 study: Coarse Himalayan pink salt had highest microplastics load of tested salts
Heavy metalsArsenic, cadmium detected in some samples
Mineral claimsTrace minerals at nutritionally insignificant levels; would need >30g/day to matter
NTRPX Solution:
SourceFormWhy
Sodium CitrateUSP gradeProvides sodium + citrate (pH buffering); pharmaceutical purity
Sodium ChlorideUSP/Ph. Eur. gradeProvides sodium + chloride; >99.9% pure; no contaminants
Both sources are pharmaceutical grade with guaranteed purity and no heavy metal/microplastic concerns.

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🌙 Luna™ — Nighttime Hydration + Sleep

Timing

1-2 hours before bed

Serving

Mix in 12-16 oz water

Flavor

Citrus-Chamomile / Berry

Philosophy

“Hydrate while you restore”

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Luna™ Complete Formulation

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Carbohydrate System (Lower for Evening)

IngredientAmountFunctionTaste
D-Glucose Monohydrate8 gBaseline brain supportSweet ✓
Fructose4 gGentle sustained releaseVery sweet ✓
Glucose:Fructose Ratio: 67:33
Total Sugars: 12g per serving (lower for evening)

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Sleep Support Ingredients

IngredientFormDoseDomainTaste Profile
GlycinePharmaceutical grade3,000 mgCircadianSweet ✓ (naturally sweet amino acid)
Magnesium GlycinateChelated200 mg (elem.)GABAergicMild ✓
L-TheanineSuntheanine®150 mgGABAergicMild umami; easily masked ✓
TaurinePharmaceutical grade500 mgGABAergicSlightly sweet ✓
Apigenin98% extract25 mgNAD+Slight bitterness — requires masking

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Electrolyte Complex (Reduced Sodium for Night)

ElectrolyteFormDoseNotes
SodiumSodium Citrate (USP)200 mgLower at night; prevents thirst
SodiumSodium Chloride (USP)100 mgMinimal for overnight balance
PotassiumPotassium Citrate300 mgIntracellular
ZincZinc Picolinate15 mgSleep; immune; tasteless ✓
Total Sodium: 300 mg (reduced from Sol™ for evening)

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Luna™ + Recover™ Synergy

IngredientRecover™Luna™Combined
Glycine3,000 mg3,000 mg6,000 mg
Magnesium244 mg200 mg444 mg
L-Theanine200 mg150 mg350 mg
Taurine1,000 mg500 mg1,500 mg
Apigenin50 mg25 mg75 mg
Melatonin0.3 mg—0.3 mg
Zinc15 mg15 mg30 mg
Maximum Sleep Protocol: Recover™ + Luna™ together for jet lag, sleep debt recovery, or maximum overnight optimization.

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ParaCaffeine +™ — Clean Stimulation

Timing

Morning or Early Afternoon

Cutoff

2:00 PM (strict)

Format

Capsules (2 capsules)

Philosophy

“Caffeine evolved”

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ParaCaffeine +™ Complete Formulation

IngredientFormDoseDomainRationale
Paraxanthineenfinity®100 mgAdenosine2.2× A2A affinity; no anxiogenic metabolites
L-TheanineSuntheanine®200 mgGABAergicSmooths stimulation; alpha waves
CDP-CholineCognizin®100 mgCholinergicSustains ACh under stimulation
L-TyrosineNALT200 mgDopaminergicReplenishes catecholamines
TheobromineCacao-derived50 mgCardiovascularMild, longer-acting; smooth curve
B6P5P10 mgMethylationNeurotransmitter cofactor
B12Methylcobalamin250 mcgMethylationEnergy support

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Why Paraxanthine Replaces Caffeine

PropertyCaffeineParaxanthine
A2A receptor affinity1×2.2×
Half-life5-6 hours3-4 hours
MetabolitesTheophylline (anxiogenic)None problematic
Sleep interferenceHighLower
JittersCommonRare

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Sprint™ — Acute Peak Performance

Timing

60-90 min before peak demand

Frequency

1-2× per week MAXIMUM

Format

Capsules (4-6 capsules)

Philosophy

“Reserved for peak output”
Sprint™ is for ACUTE effects only.Removed from v2:
  • ❌ Phosphatidylserine — No acute effects; chronic benefit only (per monograph: “PS benefits build over time… this is not an acute-effect supplement”)
  • ❌ Lion’s Mane — Acute evidence mixed; primary NGF mechanism is chronic; moved to Boost™
These ingredients provide long-term benefits and belong in daily formulas, not acute stacks.

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Sprint™ Complete Formulation (v3 — Acute Only)

IngredientFormDoseDomainAcute Mechanism
Alpha-GPC50%600 mgCholinergicRapid high-bioavailability choline bolus
Huperzine A≥98% Synthetic Pure100 mcgCholinergicAChE inhibitor; immediate ACh amplification
CaffeineAnhydrous100 mgAdenosineBroad receptor blockade; acute power
L-TheanineSuntheanine®200 mgGABAergicPrevents overshoot; smooth focus
Mucuna pruriens15% L-DOPA500 mg (75mg L-DOPA)DopaminergicDirect DA precursor; acute drive
CDP-CholineCognizin®250 mgCholinergicSustained choline; uridine
Salidroside≥98% Precision Fermented30 mgHPA AxisAcute MAO-B inhibition; extends DA
TTFDSulbutiamine derivative50 mgMitochondrialCNS-penetrant thiamine; acute brain energy
B6P5P25 mgMethylationCritical DOPA decarboxylase cofactor
B12Methylcobalamin1,000 mcgMethylationElevated for acute demand

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Premium Form Specification

Not acceptable: “1% Huperzine A extract from Huperzia serrata”
  • Requires ~10mg extract to deliver 100mcg Huperzine A
  • Variable quality and potency
  • Sustainability concerns (endangered plant)
  • Inconsistent batches
NTRPX Standard: ≥98% Synthetic Huperzine A
  • Molecularly identical to plant-derived
  • Exact, consistent potency
  • Pharmaceutical purity — no contaminants
  • Sustainable — no wild harvesting
  • Dose precision — 100 mcg is exactly 100 mcg

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How Sprint™ Creates Maximum ACh

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Ingredient Purity Standards Summary

IngredientRequired SpecificationNOT Acceptable
Salidroside≥98% precision fermented3% Rhodiola extract
Huperzine A≥98% synthetic pure1% Huperzia serrata extract
Apigenin≥98% extract<95% or crude extract
UbiquinolKaneka UbiquinolUbiquinone; generic ubiquinol
B6Pyridoxal-5’-Phosphate (P5P)Pyridoxine HCl
B9L-5-MTHF (Quatrefolic®)Folic acid
B12Methylcobalamin + AdenosylcobalaminCyanocobalamin
CDP-CholineCognizin®Generic/unbranded
CreatineCreapure®Generic monohydrate
SodiumUSP/Ph. Eur. gradePink Himalayan; sea salt
Magnesium ThreonateMagtein®Generic; oxide; carbonate

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Document Control

VersionDateAuthorKey Changes
3.02026-01-26NTRPX R&DRemoved paraxanthine from Sol; ≥98% salidroside/huperzine; melatonin 0.3mg; removed non-acute from Sprint; pharmaceutical sodium; added glucose:fructose system; verified All Systems Go independence
The NTRPX Meta System™ v3 is now fully corrected with premium ingredient forms, proper taste considerations for drink mixes, physiological melatonin dosing, acute-only Sprint™ formulation, and pharmaceutical-grade electrolyte sources.