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NTRPX Systems — Complete Formulations

All Systems Go™

3 Formulas · Daily Protocol

Neuraldrink™

2 Formulas · Circadian Beverages

ParaCaffeine +™

1 Formula · Clean Stimulation

Sprint™

1 Formula · Peak Performance

All Systems Go™ — Foundation System

The flagship daily protocol. Three formulations synchronized to circadian biology providing complete coverage of the 12 biological domains.

☀️ Boost™ — Morning Activation

Timing

6:00 - 10:00 AM

With Food

Light breakfast

Primary Targets

Cholinergic · Dopaminergic · Mitochondrial

Philosophy

“Wake up sharp, not wired”

Boost™ Ingredient Specifications

IngredientFormDoseDomainMechanismEvidence
CDP-CholineCognizin®300 mgCholinergicCholine + uridine donor; ACh synthesisTIER 1
L-TyrosineN-Acetyl-L-Tyrosine500 mgDopaminergicDA/NE precursor; stress resilienceTIER 1
CreatineCreapure® Monohydrate2.5 gATP SystemsPhosphocreatine buffer; cognitive reserveTIER 1
PQQBioPQQ®20 mgMitochondrialPGC-1α activation; biogenesisTIER 2
CoQ10Kaneka Ubiquinol100 mgMitochondrialElectron transport; ATP productionTIER 1
SalidrosideRhodiola 3% standardized100 mg salidrosideHPA AxisMAO-B inhibition; adaptogenicTIER 2
Lion’s ManeFruiting body + mycelium500 mgNeuroprotectionNGF/BDNF stimulationTIER 2

Boost™ B-Complex (Active Forms)

VitaminFormDoseRationale
B1Benfotiamine150 mgHigh-bioavailability thiamine; AGE inhibition
B1TTFD (Sulbutiamine)50 mgCNS-penetrant thiamine; cognitive energy
B2Riboflavin-5’-Phosphate15 mgActive coenzyme; supports B6/B9/B3
B3Nicotinamide100 mgNAD+ precursor; morning energy
B5D-Calcium Pantothenate50 mgCoA synthesis
B6Pyridoxal-5’-Phosphate15 mgNeurotransmitter synthesis; ONLY safe form
B7D-Biotin300 mcgCarboxylase support
B9L-5-MTHF (Quatrefolic®)400 mcgActive folate; bypasses MTHFR
B12Methylcobalamin500 mcgCytoplasmic coenzyme; methylation
B12Adenosylcobalamin250 mcgMitochondrial coenzyme

Boost™ Mechanism Map

Why These Specific Doses?

IngredientDoseRationale
CDP-Choline 300mgSplit daily total of 500-600mg between Boost/Sustain; acute cognitive dose range 250-500mg
L-Tyrosine 500mgEffective cognitive dose 500-2000mg; 500mg morning provides substrate without overload
Creatine 2.5gCombined with Sol™ (2.5g) = 5g/day maintenance dose; split improves absorption
PQQ 20mgClinical dose for cognitive effects (Itoh et al. 2016); BioPQQ® studied dose
CoQ10 100mgUbiquinol effective at 100-200mg; higher absorption than ubiquinone
Salidroside 100mgStandardized to 3% from ~330mg Rhodiola extract; clinically effective range
Lion’s Mane 500mgModerate chronic dose; Mori et al. used 3g/day but saw effects at lower doses
B-vitaminsTherapeutic doses of active forms; well above RDA for optimization

🌤️ Sustain™ — Daytime Performance

Timing

10:00 AM - 2:00 PM

With Food

With lunch

Primary Targets

Cholinergic · Membrane · Memory · Alertness

Philosophy

“All-day cognitive endurance”

Sustain™ Ingredient Specifications

IngredientFormDoseDomainMechanismEvidence
CDP-CholineCognizin®250 mgCholinergicContinued ACh support; uridineTIER 1
PhosphatidylserineSharp-PS® (sunflower)100 mgNeuroprotectionMembrane fluidity; cortisol modulationTIER 1
Paraxanthineenfinity®100 mgAdenosineClean A2A antagonism; alert without anxiousTIER 2
L-TheanineSuntheanine®100 mgGABAergicBalances paraxanthine; alpha wavesTIER 1
Bacopa monnieriBaCognize® 45% bacosides300 mgNeuroprotectionMemory consolidation; serotonergicTIER 1
AshwagandhaKSM-66®300 mgHPA AxisCortisol reduction; GABAergicTIER 1
Saffronaffron®28 mgSerotonergicSerotonin reuptake; moodTIER 2
DHALife’s DHA® (algal)250 mgStructuralNeuronal membrane; synapticTIER 1
EPAAlgal125 mgCardiovascularAnti-inflammatory; moodTIER 1

Sustain™ B-Complex Continuation

VitaminFormDoseRationale
B1Benfotiamine100 mgContinued metabolic support
B2Riboflavin-5’-Phosphate10 mgCofactor maintenance
B5D-Calcium Pantothenate50 mgCoA synthesis
B6Pyridoxal-5’-Phosphate10 mgNeurotransmitter maintenance
B12Adenosylcobalamin250 mcgMitochondrial B12 complement

Sustain™ Mechanism Map

Why Paraxanthine Replaces Caffeine

PropertyCaffeineParaxanthine
A2A receptor affinity2.2×
Half-life5-6 hours3-4 hours
MetabolitesTheobromine (long t½), Theophylline (anxiogenic)None problematic
Jitters/anxietyCommonRare
Sleep interferenceHigh (long clearance)Lower (faster clearance)
ToleranceRapidSlower
Paraxanthine IS caffeine’s primary active metabolite — the compound responsible for most cognitive benefits. By supplementing directly, you skip the problematic metabolites.

🌙 Recover™ — Evening Recovery

Timing

30-60 min before bed

With Food

Light or without

Primary Targets

GABAergic · Circadian · NAD+ · Repair

Philosophy

“Sleep deep, wake restored”

Recover™ Ingredient Specifications

IngredientFormDoseDomainMechanismEvidence
GlycinePharmaceutical grade3,000 mgCircadianNMDA → hypothalamus → core temp ↓0.3°CTIER 1
Magnesium L-ThreonateMagtein®144 mg elementalGABAergicBrain-penetrant; synaptic plasticityTIER 2
Magnesium GlycinateChelated100 mg elementalGABAergicGABA potentiation; +400mg glycineTIER 1
L-TheanineSuntheanine®200 mgGABAergicAlpha waves; GABA/glutamate balanceTIER 1
Apigenin98% extract50 mgNAD+, GABAergicCD38 inhibition; anxiolyticTIER 2
TaurinePharmaceutical grade1,000 mgGABAergicGABA-A agonist; inhibitory toneTIER 2
NRNiagen®300 mgNAD+ MetabolismNAD+ for overnight repair; sirtuinsTIER 2
ZincZinc Picolinate15 mgCellular RepairImmune; sleep regulationTIER 1

Recover™ Evening B-Vitamins

VitaminFormDoseRationale
B6Pyridoxal-5’-Phosphate10 mgGABA synthesis cofactor
B9L-5-MTHF400 mcgMethylation support continues overnight
B12Methylcobalamin250 mcgNo sleep interference; supports repair

Recover™ Mechanism Map

Why Exactly 3g Glycine?

DoseEffectClinical Evidence
< 3gInsufficient hypothalamic signalingSubtherapeutic
= 3gReliable 0.3°C core temperature drop; improved sleep qualityBannai 2012, Inagawa 2006
> 3gNo additional benefitDose-response plateaus
This is NOT sedation. Glycine triggers the body’s OWN sleep-onset mechanism. The temperature drop is what signals “time to sleep” — the same process that happens naturally when you get sleepy.

CD38 Inhibition Preserves NAD+

The Problem: CD38 is a major NAD+ consumer, degrading much of the NAD+ you produce.The Solution: Apigenin inhibits CD38, preserving the NAD+ generated from NR supplementation. This synergy maximizes overnight repair processes.

All Systems Go™ Daily Totals

All Systems Go™ Combined Daily Intake

IngredientBoost™Sustain™Recover™Daily Total
CDP-Choline300 mg250 mg550 mg
L-Tyrosine500 mg500 mg
Creatine2,500 mg2,500 mg
PQQ20 mg20 mg
CoQ10100 mg100 mg
Salidroside100 mg100 mg
Lion’s Mane500 mg500 mg
Phosphatidylserine100 mg100 mg
Paraxanthine100 mg100 mg
L-Theanine100 mg200 mg300 mg
Bacopa300 mg300 mg
Ashwagandha300 mg300 mg
Saffron28 mg28 mg
DHA250 mg250 mg
EPA125 mg125 mg
Glycine3,000 mg3,000 mg
Mg L-Threonate144 mg144 mg (elemental)
Mg Glycinate100 mg100 mg (elemental)
Apigenin50 mg50 mg
Taurine1,000 mg1,000 mg
NR300 mg300 mg
Zinc15 mg15 mg

B-Vitamin Daily Totals (All Systems Go™)

VitaminFormBoost™Sustain™Recover™Daily Total
B1Benfotiamine150 mg100 mg250 mg
B1TTFD50 mg50 mg
B2R5P15 mg10 mg25 mg
B3Nicotinamide100 mg100 mg
B5Calcium Pantothenate50 mg50 mg100 mg
B6P5P15 mg10 mg10 mg35 mg
B7D-Biotin300 mcg300 mcg
B9L-5-MTHF400 mcg400 mcg800 mcg
B12Methylcobalamin500 mcg250 mcg750 mcg
B12Adenosylcobalamin250 mcg250 mcg500 mcg

Neuraldrink™ — Circadian Beverages

Precision-formulated hydration synchronized to circadian biology.

☀️ Sol™ — Daytime Hydration + Energy

Timing

Morning through Early Afternoon

Serving

Mix in 16-20 oz water

Primary Targets

Hydration · ATP · NO · Adaptogens

Philosophy

“Clean energy that sustains”

Sol™ Ingredient Specifications

IngredientFormDoseDomainMechanismEvidence
Paraxanthineenfinity®100 mgAdenosineA2A antagonism; clean alertnessTIER 2
CreatineCreapure® Monohydrate2,500 mgATP SystemsPhosphocreatine; cognitive + physicalTIER 1
L-TyrosineN-Acetyl-L-Tyrosine300 mgDopaminergicDA/NE precursorTIER 1
L-CitrullineFree form3,000 mgCardiovascularNO production; blood flowTIER 1
CordycepsCS-4 standardized1,500 mgMitochondrialO₂ utilization; AMPK; adenosineTIER 2
Rhodiola3% salidroside150 mg (4.5mg salidroside)HPA AxisAdaptogenic; fatigue resistanceTIER 2
TaurinePharmaceutical grade1,000 mgCellularOsmoregulation; antioxidantTIER 1

Sol™ Electrolyte Complex

ElectrolyteFormDoseRationale
SodiumCitrate + Pink Himalayan1,000 mgPrimary hydration driver
PotassiumCitrate500 mgIntracellular balance
MagnesiumCitrate100 mgCofactor; muscle function
ChlorideFrom sodium chloride400 mgFluid balance
CalciumCitrate100 mgNerve transmission

Sol™ B-Vitamin Hydration Complex

VitaminFormDoseRationale
B1Thiamine HCl25 mgSweat loss replacement
B2R5P10 mgEnergy metabolism
B3Niacinamide50 mgNAD+ support
B5Calcium Pantothenate25 mgCoA synthesis
B6P5P10 mgAmino acid metabolism
B12Methylcobalamin250 mcgEnergy; nerve function
Vitamin CAscorbic Acid100 mgAntioxidant; collagen

Why L-Citrulline Over L-Arginine

After comprehensive evaluation (see: L-Citrulline Evaluation, L-Arginine Evaluation, Nitrosigine Comparison), L-Citrulline is selected for Sol™:
FactorL-ArginineL-CitrullineWinner
Oral bioavailability~20%~80%Citrulline
First-pass metabolismExtensiveMinimalCitrulline
Plasma arginine increaseModest, briefSustained, significantCitrulline
GI toleranceIssues at >6gWell-tolerated at 6g+Citrulline
Effective dose6-10g (impractical)3-6g (feasible)Citrulline
Arginase bypassNoYesCitrulline
3g L-Citrulline in Sol™ provides superior NO production compared to equivalent or higher arginine doses.

Why Cordyceps in Sol™

Cordyceps militaris / CS-4 provides unique benefits for a daytime energy drink:
MechanismEffectApplication
Adenosine analogModulates adenosine receptorsSynergizes with paraxanthine
AMPK activationCellular energy sensingMetabolic efficiency
↑ Oxygen utilizationImproved VO2Endurance; altitude adaptation
ATP productionDirect mitochondrial supportSustained energy
1.5g daily dose based on clinical studies showing endurance benefits.

🌙 Luna™ — Nighttime Hydration + Sleep

Timing

1-2 hours before bed

Serving

Mix in 12-16 oz water

Primary Targets

Hydration · Thermoregulation · Sleep Architecture

Philosophy

“Hydrate while you restore”

Luna™ Ingredient Specifications

IngredientFormDoseDomainMechanismEvidence
GlycinePharmaceutical grade3,000 mgCircadianCore temp ↓0.3°C; sleep onsetTIER 1
Magnesium GlycinateChelated200 mg elementalGABAergicGABA potentiation; +800mg glycineTIER 1
L-TheanineSuntheanine®150 mgGABAergicAlpha waves; relaxationTIER 1
TaurinePharmaceutical grade500 mgGABAergicGABA-A agonismTIER 2
Apigenin98% extract25 mgNAD+, GABAergicCD38 inhibition; anxiolyticTIER 2

Luna™ Electrolyte Complex (Reduced Sodium for Night)

ElectrolyteFormDoseRationale
SodiumCitrate300 mgLower than Sol™; prevents nighttime thirst
PotassiumCitrate300 mgIntracellular balance maintained
MagnesiumFrom Glycinate above(included)Higher for sleep
ZincPicolinate15 mgSleep regulation; overnight immune

Luna™ Synergy with Recover™

IngredientRecover™Luna™CombinedEffect
Glycine3,000 mg3,000 mg6,000 mgMaximum thermoregulation
Magnesium244 mg200 mg444 mgFull coverage
L-Theanine200 mg150 mg350 mgEnhanced alpha waves
Taurine1,000 mg500 mg1,500 mgStrong GABA tone
Apigenin50 mg25 mg75 mgRobust CD38 inhibition
Maximum Sleep Protocol: Recover™ + Luna™ together provides the most comprehensive sleep support in the NTRPX system. Use for jet lag, sleep debt recovery, or maximum recovery needs.

ParaCaffeine +™ — Clean Stimulation

Timing

Morning or Early Afternoon

Cutoff

2:00 PM (strict)

Frequency

As needed; sustainable daily use OK

Philosophy

“Caffeine evolved — no jitters, no crash”

ParaCaffeine +™ Ingredient Specifications

IngredientFormDoseDomainMechanismEvidence
Paraxanthineenfinity®100 mgAdenosineA2A antagonism 2.2×; clean alertnessTIER 2
L-TheanineSuntheanine®200 mgGABAergicSmooths stimulation; alpha wavesTIER 1
CDP-CholineCognizin®100 mgCholinergicSustains ACh under stimulationTIER 1
L-TyrosineNALT200 mgDopaminergicReplenishes catecholaminesTIER 1
TheobromineCacao-derived50 mgCardiovascularMild vasodilation; smooth curveTIER 2
B6P5P10 mgMethylationNeurotransmitter cofactorTIER 1
B12Methylcobalamin250 mcgMethylationEnergy; nerve functionTIER 1

ParaCaffeine +™ Mechanism Map

The Cofactor Strategy

CofactorProblem It SolvesMechanism
L-Theanine 200mgStimulants → jitters/anxietyPromotes alpha waves; GABA/glutamate balance
CDP-Choline 100mgStimulants deplete AChProvides choline substrate
L-Tyrosine 200mgStimulants deplete catecholaminesReplenishes DA/NE precursor
Theobromine 50mgEnergy curve too sharpMild, longer-acting; smooth transition
B6 + B12Neurotransmitter synthesis requires cofactorsEnsures adequate conversion capacity
Result: Sustainable stimulation appropriate for daily use without the downsides of caffeine.

Sprint™ — Acute Peak Performance

Timing

60-90 min before peak demand

Frequency

1-2× per week MAXIMUM

Replaces

Boost™ on event days

Philosophy

“Reserved for when you need peak output”
Sprint™ is NOT for daily use. It is designed for high-stakes cognitive events — presentations, exams, competitions, critical deadlines. Daily use will cause tolerance, receptor downregulation, and diminished efficacy.

Sprint™ Ingredient Specifications

IngredientFormDoseDomainMechanismEvidence
Alpha-GPC50%600 mg (300mg α-GPC)CholinergicRapid high-bioavailability cholineTIER 2
Huperzine A1% extract200 mcgCholinergicAChE inhibitor; amplifies ACh signalTIER 2
CaffeineAnhydrous100 mgAdenosineBroad receptor profile; acute powerTIER 1
L-TheanineSuntheanine®200 mgGABAergicPrevents overshoot; smooth focusTIER 1
Mucuna pruriens15% L-DOPA500 mg (75mg L-DOPA)DopaminergicDirect DA precursorTIER 2
CDP-CholineCognizin®250 mgCholinergicAdditional choline; uridineTIER 1
PhosphatidylserineSharp-PS®100 mgNeuroprotectionMembrane; cortisol modulationTIER 1
Lion’s ManeFruiting body 8:1500 mgNeuroprotectionNGF supportTIER 2
TTFDSulbutiamine derivative50 mgMitochondrialCNS-penetrant thiamineTIER 3

Sprint™ B-Vitamin Support

VitaminFormDoseRationale
B6P5P25 mgDOPA decarboxylase cofactor (critical for Mucuna)
B12Methylcobalamin1,000 mcgElevated for acute demand

Sprint™ Mechanism Map

Caffeine vs Paraxanthine for Acute Performance

For Sprint™ specifically, caffeine is preferred over paraxanthine:
FactorRationale
Broader receptor profileCaffeine blocks A1 + A2A; more complete adenosine antagonism
Faster onsetCaffeine peaks faster for acute demands
Occasional use contextSleep disruption less relevant for single events
Synergy with L-DOPATraditional, well-studied pairing
Stronger acute driveParaxanthine is “cleaner” — Sprint™ needs raw power
For daily use: Paraxanthine (ParaCaffeine +™, Sustain™, Sol™) For acute events: Caffeine (Sprint™)

The Alpha-GPC Safety Consideration

A 2021 study (Yun et al., BMJ Open) found:
  • 46% increased stroke risk with 10+ years of Alpha-GPC use
  • N = 12 million+ individuals aged 50+
  • Mechanism: possible TMAO elevation
NTRPX Decision:
  • Daily/chronic use: CDP-Choline (Boost™, Sustain™) — lower TMAO risk
  • Acute/occasional use: Alpha-GPC (Sprint™ only) — superior acute choline delivery
Sprint™ is used 1-2× per week maximum. At this frequency, Alpha-GPC provides acute benefits without chronic exposure risk.

When to Use Sprint™

✅ Appropriate❌ Not Appropriate
Major presentationDaily productivity
Final examRegular work tasks
Competition dayCatching up on sleep
Critical negotiationSocial events
Job interviewRoutine exercise
Creative deadline (acute)Ongoing projects

Event Day Protocol

TimeAction
MorningSprint™ replaces Boost™ (not in addition to)
60-90 min before eventTake Sprint™ if event is later in day
No Sustain™Optional; ride Sprint™ effects or take Sustain™ PM only
No ParaCaffeine +™Sprint™ contains caffeine
EveningRecover™ + Luna™ as normal (critical for recovery)
Next dayReturn to normal All Systems Go™ protocol

Frequency Limits

UsageAssessment
1× per week✅ Optimal; maintains efficacy
2× per week✅ Acceptable maximum
3× per week⚠️ Too frequent; reduce
Daily❌ Will cause tolerance; defeats purpose

Document Control

VersionDateAuthorChanges
2.02026-01-25NTRPX R&DComplete formulations for all 7 products

The NTRPX Meta System™ is complete. All Systems Go™ (Boost™ + Sustain™ + Recover™) provides the foundation. Neuraldrink™ (Sol™ + Luna™) amplifies with circadian hydration. ParaCaffeine +™ offers sustainable clean stimulation. Sprint™ delivers maximum acute output for high-stakes events. Together: the most comprehensive, synergistic supplementation system ever conceived.