NTRPX Systems — Complete Formulations
All Systems Go™
3 Formulas · Daily Protocol
Neuraldrink™
2 Formulas · Circadian Beverages
ParaCaffeine +™
1 Formula · Clean Stimulation
Sprint™
1 Formula · Peak Performance
All Systems Go™ — Foundation System
The flagship daily protocol. Three formulations synchronized to circadian biology providing complete coverage of the 12 biological domains.☀️ Boost™ — Morning Activation
Timing
6:00 - 10:00 AM
With Food
Light breakfast
Primary Targets
Cholinergic · Dopaminergic · Mitochondrial
Philosophy
“Wake up sharp, not wired”
Complete Formulation Table
Complete Formulation Table
Boost™ Ingredient Specifications
| Ingredient | Form | Dose | Domain | Mechanism | Evidence |
|---|---|---|---|---|---|
| CDP-Choline | Cognizin® | 300 mg | Cholinergic | Choline + uridine donor; ACh synthesis | TIER 1 |
| L-Tyrosine | N-Acetyl-L-Tyrosine | 500 mg | Dopaminergic | DA/NE precursor; stress resilience | TIER 1 |
| Creatine | Creapure® Monohydrate | 2.5 g | ATP Systems | Phosphocreatine buffer; cognitive reserve | TIER 1 |
| PQQ | BioPQQ® | 20 mg | Mitochondrial | PGC-1α activation; biogenesis | TIER 2 |
| CoQ10 | Kaneka Ubiquinol | 100 mg | Mitochondrial | Electron transport; ATP production | TIER 1 |
| Salidroside | Rhodiola 3% standardized | 100 mg salidroside | HPA Axis | MAO-B inhibition; adaptogenic | TIER 2 |
| Lion’s Mane | Fruiting body + mycelium | 500 mg | Neuroprotection | NGF/BDNF stimulation | TIER 2 |
Boost™ B-Complex (Active Forms)
| Vitamin | Form | Dose | Rationale |
|---|---|---|---|
| B1 | Benfotiamine | 150 mg | High-bioavailability thiamine; AGE inhibition |
| B1 | TTFD (Sulbutiamine) | 50 mg | CNS-penetrant thiamine; cognitive energy |
| B2 | Riboflavin-5’-Phosphate | 15 mg | Active coenzyme; supports B6/B9/B3 |
| B3 | Nicotinamide | 100 mg | NAD+ precursor; morning energy |
| B5 | D-Calcium Pantothenate | 50 mg | CoA synthesis |
| B6 | Pyridoxal-5’-Phosphate | 15 mg | Neurotransmitter synthesis; ONLY safe form |
| B7 | D-Biotin | 300 mcg | Carboxylase support |
| B9 | L-5-MTHF (Quatrefolic®) | 400 mcg | Active folate; bypasses MTHFR |
| B12 | Methylcobalamin | 500 mcg | Cytoplasmic coenzyme; methylation |
| B12 | Adenosylcobalamin | 250 mcg | Mitochondrial coenzyme |
Boost™ Mechanism Map
Dosing Rationale
Dosing Rationale
Why These Specific Doses?
| Ingredient | Dose | Rationale |
|---|---|---|
| CDP-Choline 300mg | Split daily total of 500-600mg between Boost/Sustain; acute cognitive dose range 250-500mg | |
| L-Tyrosine 500mg | Effective cognitive dose 500-2000mg; 500mg morning provides substrate without overload | |
| Creatine 2.5g | Combined with Sol™ (2.5g) = 5g/day maintenance dose; split improves absorption | |
| PQQ 20mg | Clinical dose for cognitive effects (Itoh et al. 2016); BioPQQ® studied dose | |
| CoQ10 100mg | Ubiquinol effective at 100-200mg; higher absorption than ubiquinone | |
| Salidroside 100mg | Standardized to 3% from ~330mg Rhodiola extract; clinically effective range | |
| Lion’s Mane 500mg | Moderate chronic dose; Mori et al. used 3g/day but saw effects at lower doses | |
| B-vitamins | Therapeutic doses of active forms; well above RDA for optimization |
🌤️ Sustain™ — Daytime Performance
Timing
10:00 AM - 2:00 PM
With Food
With lunch
Primary Targets
Cholinergic · Membrane · Memory · Alertness
Philosophy
“All-day cognitive endurance”
Complete Formulation Table
Complete Formulation Table
Sustain™ Ingredient Specifications
| Ingredient | Form | Dose | Domain | Mechanism | Evidence |
|---|---|---|---|---|---|
| CDP-Choline | Cognizin® | 250 mg | Cholinergic | Continued ACh support; uridine | TIER 1 |
| Phosphatidylserine | Sharp-PS® (sunflower) | 100 mg | Neuroprotection | Membrane fluidity; cortisol modulation | TIER 1 |
| Paraxanthine | enfinity® | 100 mg | Adenosine | Clean A2A antagonism; alert without anxious | TIER 2 |
| L-Theanine | Suntheanine® | 100 mg | GABAergic | Balances paraxanthine; alpha waves | TIER 1 |
| Bacopa monnieri | BaCognize® 45% bacosides | 300 mg | Neuroprotection | Memory consolidation; serotonergic | TIER 1 |
| Ashwagandha | KSM-66® | 300 mg | HPA Axis | Cortisol reduction; GABAergic | TIER 1 |
| Saffron | affron® | 28 mg | Serotonergic | Serotonin reuptake; mood | TIER 2 |
| DHA | Life’s DHA® (algal) | 250 mg | Structural | Neuronal membrane; synaptic | TIER 1 |
| EPA | Algal | 125 mg | Cardiovascular | Anti-inflammatory; mood | TIER 1 |
Sustain™ B-Complex Continuation
| Vitamin | Form | Dose | Rationale |
|---|---|---|---|
| B1 | Benfotiamine | 100 mg | Continued metabolic support |
| B2 | Riboflavin-5’-Phosphate | 10 mg | Cofactor maintenance |
| B5 | D-Calcium Pantothenate | 50 mg | CoA synthesis |
| B6 | Pyridoxal-5’-Phosphate | 10 mg | Neurotransmitter maintenance |
| B12 | Adenosylcobalamin | 250 mcg | Mitochondrial B12 complement |
Sustain™ Mechanism Map
Paraxanthine vs Caffeine
Paraxanthine vs Caffeine
Why Paraxanthine Replaces Caffeine
| Property | Caffeine | Paraxanthine |
|---|---|---|
| A2A receptor affinity | 1× | 2.2× |
| Half-life | 5-6 hours | 3-4 hours |
| Metabolites | Theobromine (long t½), Theophylline (anxiogenic) | None problematic |
| Jitters/anxiety | Common | Rare |
| Sleep interference | High (long clearance) | Lower (faster clearance) |
| Tolerance | Rapid | Slower |
🌙 Recover™ — Evening Recovery
Timing
30-60 min before bed
With Food
Light or without
Primary Targets
GABAergic · Circadian · NAD+ · Repair
Philosophy
“Sleep deep, wake restored”
Complete Formulation Table
Complete Formulation Table
Recover™ Ingredient Specifications
| Ingredient | Form | Dose | Domain | Mechanism | Evidence |
|---|---|---|---|---|---|
| Glycine | Pharmaceutical grade | 3,000 mg | Circadian | NMDA → hypothalamus → core temp ↓0.3°C | TIER 1 |
| Magnesium L-Threonate | Magtein® | 144 mg elemental | GABAergic | Brain-penetrant; synaptic plasticity | TIER 2 |
| Magnesium Glycinate | Chelated | 100 mg elemental | GABAergic | GABA potentiation; +400mg glycine | TIER 1 |
| L-Theanine | Suntheanine® | 200 mg | GABAergic | Alpha waves; GABA/glutamate balance | TIER 1 |
| Apigenin | 98% extract | 50 mg | NAD+, GABAergic | CD38 inhibition; anxiolytic | TIER 2 |
| Taurine | Pharmaceutical grade | 1,000 mg | GABAergic | GABA-A agonist; inhibitory tone | TIER 2 |
| NR | Niagen® | 300 mg | NAD+ Metabolism | NAD+ for overnight repair; sirtuins | TIER 2 |
| Zinc | Zinc Picolinate | 15 mg | Cellular Repair | Immune; sleep regulation | TIER 1 |
Recover™ Evening B-Vitamins
| Vitamin | Form | Dose | Rationale |
|---|---|---|---|
| B6 | Pyridoxal-5’-Phosphate | 10 mg | GABA synthesis cofactor |
| B9 | L-5-MTHF | 400 mcg | Methylation support continues overnight |
| B12 | Methylcobalamin | 250 mcg | No sleep interference; supports repair |
Recover™ Mechanism Map
The Glycine Thermoregulation Mechanism
The Glycine Thermoregulation Mechanism
Why Exactly 3g Glycine?
| Dose | Effect | Clinical Evidence |
|---|---|---|
| < 3g | Insufficient hypothalamic signaling | Subtherapeutic |
| = 3g | Reliable 0.3°C core temperature drop; improved sleep quality | Bannai 2012, Inagawa 2006 |
| > 3g | No additional benefit | Dose-response plateaus |
The Apigenin + NR Synergy
The Apigenin + NR Synergy
CD38 Inhibition Preserves NAD+
The Problem: CD38 is a major NAD+ consumer, degrading much of the NAD+ you produce.The Solution: Apigenin inhibits CD38, preserving the NAD+ generated from NR supplementation. This synergy maximizes overnight repair processes.All Systems Go™ Daily Totals
Complete Daily Intake Summary
Complete Daily Intake Summary
All Systems Go™ Combined Daily Intake
| Ingredient | Boost™ | Sustain™ | Recover™ | Daily Total |
|---|---|---|---|---|
| CDP-Choline | 300 mg | 250 mg | — | 550 mg |
| L-Tyrosine | 500 mg | — | — | 500 mg |
| Creatine | 2,500 mg | — | — | 2,500 mg |
| PQQ | 20 mg | — | — | 20 mg |
| CoQ10 | 100 mg | — | — | 100 mg |
| Salidroside | 100 mg | — | — | 100 mg |
| Lion’s Mane | 500 mg | — | — | 500 mg |
| Phosphatidylserine | — | 100 mg | — | 100 mg |
| Paraxanthine | — | 100 mg | — | 100 mg |
| L-Theanine | — | 100 mg | 200 mg | 300 mg |
| Bacopa | — | 300 mg | — | 300 mg |
| Ashwagandha | — | 300 mg | — | 300 mg |
| Saffron | — | 28 mg | — | 28 mg |
| DHA | — | 250 mg | — | 250 mg |
| EPA | — | 125 mg | — | 125 mg |
| Glycine | — | — | 3,000 mg | 3,000 mg |
| Mg L-Threonate | — | — | 144 mg | 144 mg (elemental) |
| Mg Glycinate | — | — | 100 mg | 100 mg (elemental) |
| Apigenin | — | — | 50 mg | 50 mg |
| Taurine | — | — | 1,000 mg | 1,000 mg |
| NR | — | — | 300 mg | 300 mg |
| Zinc | — | — | 15 mg | 15 mg |
B-Vitamin Daily Totals (All Systems Go™)
| Vitamin | Form | Boost™ | Sustain™ | Recover™ | Daily Total |
|---|---|---|---|---|---|
| B1 | Benfotiamine | 150 mg | 100 mg | — | 250 mg |
| B1 | TTFD | 50 mg | — | — | 50 mg |
| B2 | R5P | 15 mg | 10 mg | — | 25 mg |
| B3 | Nicotinamide | 100 mg | — | — | 100 mg |
| B5 | Calcium Pantothenate | 50 mg | 50 mg | — | 100 mg |
| B6 | P5P | 15 mg | 10 mg | 10 mg | 35 mg |
| B7 | D-Biotin | 300 mcg | — | — | 300 mcg |
| B9 | L-5-MTHF | 400 mcg | — | 400 mcg | 800 mcg |
| B12 | Methylcobalamin | 500 mcg | — | 250 mcg | 750 mcg |
| B12 | Adenosylcobalamin | 250 mcg | 250 mcg | — | 500 mcg |
Neuraldrink™ — Circadian Beverages
Precision-formulated hydration synchronized to circadian biology.☀️ Sol™ — Daytime Hydration + Energy
Timing
Morning through Early Afternoon
Serving
Mix in 16-20 oz water
Primary Targets
Hydration · ATP · NO · Adaptogens
Philosophy
“Clean energy that sustains”
Complete Formulation Table
Complete Formulation Table
Sol™ Ingredient Specifications
| Ingredient | Form | Dose | Domain | Mechanism | Evidence |
|---|---|---|---|---|---|
| Paraxanthine | enfinity® | 100 mg | Adenosine | A2A antagonism; clean alertness | TIER 2 |
| Creatine | Creapure® Monohydrate | 2,500 mg | ATP Systems | Phosphocreatine; cognitive + physical | TIER 1 |
| L-Tyrosine | N-Acetyl-L-Tyrosine | 300 mg | Dopaminergic | DA/NE precursor | TIER 1 |
| L-Citrulline | Free form | 3,000 mg | Cardiovascular | NO production; blood flow | TIER 1 |
| Cordyceps | CS-4 standardized | 1,500 mg | Mitochondrial | O₂ utilization; AMPK; adenosine | TIER 2 |
| Rhodiola | 3% salidroside | 150 mg (4.5mg salidroside) | HPA Axis | Adaptogenic; fatigue resistance | TIER 2 |
| Taurine | Pharmaceutical grade | 1,000 mg | Cellular | Osmoregulation; antioxidant | TIER 1 |
Sol™ Electrolyte Complex
| Electrolyte | Form | Dose | Rationale |
|---|---|---|---|
| Sodium | Citrate + Pink Himalayan | 1,000 mg | Primary hydration driver |
| Potassium | Citrate | 500 mg | Intracellular balance |
| Magnesium | Citrate | 100 mg | Cofactor; muscle function |
| Chloride | From sodium chloride | 400 mg | Fluid balance |
| Calcium | Citrate | 100 mg | Nerve transmission |
Sol™ B-Vitamin Hydration Complex
| Vitamin | Form | Dose | Rationale |
|---|---|---|---|
| B1 | Thiamine HCl | 25 mg | Sweat loss replacement |
| B2 | R5P | 10 mg | Energy metabolism |
| B3 | Niacinamide | 50 mg | NAD+ support |
| B5 | Calcium Pantothenate | 25 mg | CoA synthesis |
| B6 | P5P | 10 mg | Amino acid metabolism |
| B12 | Methylcobalamin | 250 mcg | Energy; nerve function |
| Vitamin C | Ascorbic Acid | 100 mg | Antioxidant; collagen |
The L-Citrulline Decision
The L-Citrulline Decision
Why L-Citrulline Over L-Arginine
After comprehensive evaluation (see: L-Citrulline Evaluation, L-Arginine Evaluation, Nitrosigine Comparison), L-Citrulline is selected for Sol™:| Factor | L-Arginine | L-Citrulline | Winner |
|---|---|---|---|
| Oral bioavailability | ~20% | ~80% | Citrulline |
| First-pass metabolism | Extensive | Minimal | Citrulline |
| Plasma arginine increase | Modest, brief | Sustained, significant | Citrulline |
| GI tolerance | Issues at >6g | Well-tolerated at 6g+ | Citrulline |
| Effective dose | 6-10g (impractical) | 3-6g (feasible) | Citrulline |
| Arginase bypass | No | Yes | Citrulline |
Cordyceps: The Oxygen Optimizer
Cordyceps: The Oxygen Optimizer
Why Cordyceps in Sol™
Cordyceps militaris / CS-4 provides unique benefits for a daytime energy drink:| Mechanism | Effect | Application |
|---|---|---|
| Adenosine analog | Modulates adenosine receptors | Synergizes with paraxanthine |
| AMPK activation | Cellular energy sensing | Metabolic efficiency |
| ↑ Oxygen utilization | Improved VO2 | Endurance; altitude adaptation |
| ATP production | Direct mitochondrial support | Sustained energy |
🌙 Luna™ — Nighttime Hydration + Sleep
Timing
1-2 hours before bed
Serving
Mix in 12-16 oz water
Primary Targets
Hydration · Thermoregulation · Sleep Architecture
Philosophy
“Hydrate while you restore”
Complete Formulation Table
Complete Formulation Table
Luna™ Ingredient Specifications
| Ingredient | Form | Dose | Domain | Mechanism | Evidence |
|---|---|---|---|---|---|
| Glycine | Pharmaceutical grade | 3,000 mg | Circadian | Core temp ↓0.3°C; sleep onset | TIER 1 |
| Magnesium Glycinate | Chelated | 200 mg elemental | GABAergic | GABA potentiation; +800mg glycine | TIER 1 |
| L-Theanine | Suntheanine® | 150 mg | GABAergic | Alpha waves; relaxation | TIER 1 |
| Taurine | Pharmaceutical grade | 500 mg | GABAergic | GABA-A agonism | TIER 2 |
| Apigenin | 98% extract | 25 mg | NAD+, GABAergic | CD38 inhibition; anxiolytic | TIER 2 |
Luna™ Electrolyte Complex (Reduced Sodium for Night)
| Electrolyte | Form | Dose | Rationale |
|---|---|---|---|
| Sodium | Citrate | 300 mg | Lower than Sol™; prevents nighttime thirst |
| Potassium | Citrate | 300 mg | Intracellular balance maintained |
| Magnesium | From Glycinate above | (included) | Higher for sleep |
| Zinc | Picolinate | 15 mg | Sleep regulation; overnight immune |
Luna™ Synergy with Recover™
| Ingredient | Recover™ | Luna™ | Combined | Effect |
|---|---|---|---|---|
| Glycine | 3,000 mg | 3,000 mg | 6,000 mg | Maximum thermoregulation |
| Magnesium | 244 mg | 200 mg | 444 mg | Full coverage |
| L-Theanine | 200 mg | 150 mg | 350 mg | Enhanced alpha waves |
| Taurine | 1,000 mg | 500 mg | 1,500 mg | Strong GABA tone |
| Apigenin | 50 mg | 25 mg | 75 mg | Robust CD38 inhibition |
Maximum Sleep Protocol: Recover™ + Luna™ together provides the most comprehensive sleep support in the NTRPX system. Use for jet lag, sleep debt recovery, or maximum recovery needs.
ParaCaffeine +™ — Clean Stimulation
Timing
Morning or Early Afternoon
Cutoff
2:00 PM (strict)
Frequency
As needed; sustainable daily use OK
Philosophy
“Caffeine evolved — no jitters, no crash”
Complete Formulation Table
Complete Formulation Table
ParaCaffeine +™ Ingredient Specifications
| Ingredient | Form | Dose | Domain | Mechanism | Evidence |
|---|---|---|---|---|---|
| Paraxanthine | enfinity® | 100 mg | Adenosine | A2A antagonism 2.2×; clean alertness | TIER 2 |
| L-Theanine | Suntheanine® | 200 mg | GABAergic | Smooths stimulation; alpha waves | TIER 1 |
| CDP-Choline | Cognizin® | 100 mg | Cholinergic | Sustains ACh under stimulation | TIER 1 |
| L-Tyrosine | NALT | 200 mg | Dopaminergic | Replenishes catecholamines | TIER 1 |
| Theobromine | Cacao-derived | 50 mg | Cardiovascular | Mild vasodilation; smooth curve | TIER 2 |
| B6 | P5P | 10 mg | Methylation | Neurotransmitter cofactor | TIER 1 |
| B12 | Methylcobalamin | 250 mcg | Methylation | Energy; nerve function | TIER 1 |
ParaCaffeine +™ Mechanism Map
Why These Cofactors?
Why These Cofactors?
The Cofactor Strategy
| Cofactor | Problem It Solves | Mechanism |
|---|---|---|
| L-Theanine 200mg | Stimulants → jitters/anxiety | Promotes alpha waves; GABA/glutamate balance |
| CDP-Choline 100mg | Stimulants deplete ACh | Provides choline substrate |
| L-Tyrosine 200mg | Stimulants deplete catecholamines | Replenishes DA/NE precursor |
| Theobromine 50mg | Energy curve too sharp | Mild, longer-acting; smooth transition |
| B6 + B12 | Neurotransmitter synthesis requires cofactors | Ensures adequate conversion capacity |
Sprint™ — Acute Peak Performance
Timing
60-90 min before peak demand
Frequency
1-2× per week MAXIMUM
Replaces
Boost™ on event days
Philosophy
“Reserved for when you need peak output”
Complete Formulation Table
Complete Formulation Table
Sprint™ Ingredient Specifications
| Ingredient | Form | Dose | Domain | Mechanism | Evidence |
|---|---|---|---|---|---|
| Alpha-GPC | 50% | 600 mg (300mg α-GPC) | Cholinergic | Rapid high-bioavailability choline | TIER 2 |
| Huperzine A | 1% extract | 200 mcg | Cholinergic | AChE inhibitor; amplifies ACh signal | TIER 2 |
| Caffeine | Anhydrous | 100 mg | Adenosine | Broad receptor profile; acute power | TIER 1 |
| L-Theanine | Suntheanine® | 200 mg | GABAergic | Prevents overshoot; smooth focus | TIER 1 |
| Mucuna pruriens | 15% L-DOPA | 500 mg (75mg L-DOPA) | Dopaminergic | Direct DA precursor | TIER 2 |
| CDP-Choline | Cognizin® | 250 mg | Cholinergic | Additional choline; uridine | TIER 1 |
| Phosphatidylserine | Sharp-PS® | 100 mg | Neuroprotection | Membrane; cortisol modulation | TIER 1 |
| Lion’s Mane | Fruiting body 8:1 | 500 mg | Neuroprotection | NGF support | TIER 2 |
| TTFD | Sulbutiamine derivative | 50 mg | Mitochondrial | CNS-penetrant thiamine | TIER 3 |
Sprint™ B-Vitamin Support
| Vitamin | Form | Dose | Rationale |
|---|---|---|---|
| B6 | P5P | 25 mg | DOPA decarboxylase cofactor (critical for Mucuna) |
| B12 | Methylcobalamin | 1,000 mcg | Elevated for acute demand |
Sprint™ Mechanism Map
Why Caffeine in Sprint™ (Not Paraxanthine)?
Why Caffeine in Sprint™ (Not Paraxanthine)?
Caffeine vs Paraxanthine for Acute Performance
For Sprint™ specifically, caffeine is preferred over paraxanthine:| Factor | Rationale |
|---|---|
| Broader receptor profile | Caffeine blocks A1 + A2A; more complete adenosine antagonism |
| Faster onset | Caffeine peaks faster for acute demands |
| Occasional use context | Sleep disruption less relevant for single events |
| Synergy with L-DOPA | Traditional, well-studied pairing |
| Stronger acute drive | Paraxanthine is “cleaner” — Sprint™ needs raw power |
Why Alpha-GPC Only in Sprint™?
Why Alpha-GPC Only in Sprint™?
The Alpha-GPC Safety Consideration
A 2021 study (Yun et al., BMJ Open) found:- 46% increased stroke risk with 10+ years of Alpha-GPC use
- N = 12 million+ individuals aged 50+
- Mechanism: possible TMAO elevation
- Daily/chronic use: CDP-Choline (Boost™, Sustain™) — lower TMAO risk
- Acute/occasional use: Alpha-GPC (Sprint™ only) — superior acute choline delivery
Sprint™ Usage Protocol
Sprint™ Usage Protocol
When to Use Sprint™
| ✅ Appropriate | ❌ Not Appropriate |
|---|---|
| Major presentation | Daily productivity |
| Final exam | Regular work tasks |
| Competition day | Catching up on sleep |
| Critical negotiation | Social events |
| Job interview | Routine exercise |
| Creative deadline (acute) | Ongoing projects |
Event Day Protocol
| Time | Action |
|---|---|
| Morning | Sprint™ replaces Boost™ (not in addition to) |
| 60-90 min before event | Take Sprint™ if event is later in day |
| No Sustain™ | Optional; ride Sprint™ effects or take Sustain™ PM only |
| No ParaCaffeine +™ | Sprint™ contains caffeine |
| Evening | Recover™ + Luna™ as normal (critical for recovery) |
| Next day | Return to normal All Systems Go™ protocol |
Frequency Limits
| Usage | Assessment |
|---|---|
| 1× per week | ✅ Optimal; maintains efficacy |
| 2× per week | ✅ Acceptable maximum |
| 3× per week | ⚠️ Too frequent; reduce |
| Daily | ❌ Will cause tolerance; defeats purpose |
Document Control
| Version | Date | Author | Changes |
|---|---|---|---|
| 2.0 | 2026-01-25 | NTRPX R&D | Complete formulations for all 7 products |

