NeuroStructure DHA

Boost

400 mg DHA

Sustain

200 mg DHA

Form

AvailOm® High DHA

Bioavailability

5-9× vs Ethyl Esters

The molecule that builds your brain — the single most abundant omega-3 fatty acid in the central nervous system, comprising 50% of neuronal membrane weight. Docosahexaenoic acid (DHA, 22:6n-3) isn’t merely beneficial for brain function — it’s structural. Your neurons are literally built from DHA. This 22-carbon polyunsaturated fatty acid with six double bonds creates the extraordinary membrane fluidity required for synaptic vesicle fusion, receptor conformation changes, and ion channel gating. More remarkably, DHA uniquely drives phosphatidylserine (PS) synthesis in neurons, expanding the PS pool that anchors the Akt survival pathway. When DHA is depleted, PS falls, Akt signaling collapses, and neurons become vulnerable. DHA is also the precursor to Neuroprotectin D1 (NPD1) and other specialized pro-resolving mediators that actively terminate neuroinflammation. NTRPX uses AvailOm® High DHA — a revolutionary lysine-complexed free fatty acid form with 5-9× higher bioavailability than standard fish oil — delivering the brain’s essential building block in its most absorbable state. In ASG Boost and Sustain, NeuroStructure DHA provides the molecular foundation of cognitive architecture.

Mechanism of Action

DHA (all-cis-docosa-4,7,10,13,16,19-hexaenoic acid) operates through four distinct but interconnected mechanisms:

Mechanism 1: Neuronal Membrane Architecture (Primary Mechanism)

DHA’s fundamental role is as the primary structural lipid of neuronal membranes:

Brain Region	DHA Content	Functional Significance
Gray matter	35-40% of phospholipids	Neuronal cell bodies, synapses
Synaptic membranes	60-65% of PS molecular species	Signal transmission
Retina (photoreceptors)	60% of PUFAs	Phototransduction
Hippocampus	High concentration	Learning and memory

Why Six Double Bonds Matter: DHA’s unique structure — 22 carbons with 6 cis double bonds — creates extraordinary conformational flexibility. The molecule rapidly isomerizes between thousands of conformational states, creating “loosely packed” membrane domains that allow embedded proteins to move, change shape, and function. Without adequate DHA, membrane viscosity increases, receptor function declines, and synaptic transmission becomes sluggish.

Mechanism 2: Phosphatidylserine Synthesis (Critical for Neuronal Survival)

DHA uniquely drives PS accumulation in neurons — a mechanism with profound implications for cell survival:

PS Synthesis Step	DHA’s Role	Evidence
PSS1 substrate	18:0,22:6-PC is best substrate	Kim et al. 2004
PSS2 substrate	18:0,22:6-PE is best substrate	Wen & Kim 2007
PS accumulation	DHA uniquely increases neuronal PS	Garcia et al. 1998
Neuron-specific	Effect occurs only in neurons	Guo et al. 2007

Key Finding (Kim Laboratory, NIH): DHA-containing phospholipids (PC and PE) are the preferred substrates for phosphatidylserine synthase enzymes. When neurons are supplemented with DHA, PS content increases specifically in neuronal cells — not in other cell types like CHO-K1 or HEK-293. This neuron-specific PS expansion has profound consequences:

PS provides the docking site for Akt’s PH domain
Akt membrane translocation is required for phosphorylation and activation
Activated Akt phosphorylates pro-survival targets (Bad, GSK-3β, FOXO)
Result: Enhanced neuronal survival under stress conditions

n-3 Fatty Acid Deficiency: When dietary DHA is depleted, brain PS falls by 25-35% specifically in neuronal tissues (cortex, hippocampus, olfactory bulb, retina). Liver and adrenal PS remain unchanged — demonstrating the neuron-specific nature of DHA-PS coupling.

Mechanism 3: Specialized Pro-Resolving Mediators (SPMs)

DHA is the precursor to D-series resolvins, protectins, and maresins — bioactive lipid mediators that actively resolve inflammation:

SPM	Precursor	Key Actions	Potency
Neuroprotectin D1 (NPD1)	DHA via 15-LOX	Neuroprotection, anti-Aβ, anti-apoptotic	Picomolar
Resolvin D1 (RvD1)	DHA via 15-LOX/5-LOX	Stops neutrophil transmigration	Nanomolar
Resolvin D2 (RvD2)	DHA via 15-LOX/5-LOX	Reduces inflammatory cytokines	Nanomolar
Maresin 1 (MaR1)	DHA via 12-LOX	Promotes macrophage efferocytosis	Nanomolar

Neuroprotectin D1 — The Brain’s Resolution Signal:

Synthesized in brain tissue from DHA in response to oxidative stress
Potent protection against amyloid-β-induced apoptosis
Inhibits COX-2 expression and pro-inflammatory gene transcription
Promotes pro-survival Bcl-2 family protein expression
Active at picomolar concentrations — extraordinarily potent

Mechanism 4: BDNF Upregulation and Neuroplasticity

DHA enhances brain-derived neurotrophic factor (BDNF) through epigenetic and transcriptional mechanisms:

BDNF Effect	DHA Contribution	Cognitive Relevance
↑ BDNF mRNA	CREB activation	Learning capacity
↑ Synaptic proteins	Synapsin-1, PSD-95, GluR-1	Memory consolidation
↑ Dendritic spines	30%+ increase in hippocampus	Neural connectivity
Enhanced LTP	Stronger synaptic potentiation	Memory formation

Molecular Identity

Property	Value
IUPAC Name	(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid
Notation	22:6(n-3) or 22:6ω3
Synonyms	Cervonic acid, DHA
Molecular Formula	C₂₂H₃₂O₂
Molecular Weight	328.49 g/mol
CAS Number	6217-54-5
Double Bonds	6 (all cis configuration)
Melting Point	-44°C (liquid at body temperature)

AvailOm® Technology

The Bioavailability Problem

Traditional omega-3 supplements face fundamental absorption challenges:

AvailOm® High DHA Specifications

Parameter	Specification
Form	Omega-3 lysine complex powder
DHA Content	≥30% free fatty acid by weight
EPA Content	~15% free fatty acid by weight
Total EPA+DHA	≥50% as free fatty acids
Lysine Content	~14% L-lysine (essential amino acid)
Appearance	Free-flowing powder
Stability	>4 years at 25°C (no refrigeration)
Regulatory	GRAS (FDA), NDI registered, Novel Food (EU)

Clinical Bioavailability Evidence

Wageningen University Study (2020):

First in-human pharmacokinetic trial
Crossover design: AvailOm® vs standard ethyl ester
Result: 5× higher AUC for AvailOm®
Faster Tmax (peak reached earlier)

BioTeSys Three-Way Crossover RCT (2024):

21 healthy subjects (10 men, 11 women)
Three-way crossover: AvailOm® vs EE vs TG
Results:

Comparison	0-12h Bioavailability	0-24h Bioavailability
AvailOm® vs Ethyl Ester	9.33× higher	8.09× higher
AvailOm® vs Triglyceride	1.57× higher	1.44× higher

Why Lysine Complexation Works

Stabilization: Lysine (cationic amino acid) forms ionic complex with free fatty acid (anionic)
Powder form: Creates stable, dry powder from liquid oil
Gastric dissociation: Complex rapidly breaks down at gastric pH
Direct absorption: Free fatty acids absorbed directly by enterocytes
No enzymatic step: Bypasses need for pancreatic lipase
No bile dependence: Absorbs efficiently regardless of dietary fat

Bonus: L-Lysine

AvailOm® provides ~14% L-lysine by weight — an essential amino acid:

Required for carnitine synthesis (fat transport into mitochondria)
Supports collagen formation
Enhances calcium absorption
Contributes to daily amino acid requirements

Clinical Evidence

DHA and Cognitive Function

Study	Population	Dose/Duration	Key Findings
Lee et al. (2013)	MCI, 12 months	1491mg DHA + 351mg EPA	↑ Short-term memory, working memory, immediate verbal memory, delayed recall
Stonehouse et al. (2013)	Healthy young adults	1160mg DHA, 6 months	↑ Episodic memory (women), ↓ RT working memory (men)
Zhang et al. (2018)	MCI, 12 months	2g DHA/day	↑ Full-scale IQ, Information, Digit Span; slowed hippocampal atrophy
Yurko-Mauro et al. (2010)	ARCD, 24 weeks	900mg DHA/day	↑ Paired associate learning (PAL) memory

DHA and Brain Volume/Structure

Zhang et al. 2016 (Tianjin, China):

240 MCI subjects, 12-month RCT
2g DHA/day vs corn oil placebo
Results:

Outcome	DHA Effect	P-value
Left hippocampal volume	Preserved	p = 0.016
Right hippocampal volume	Preserved	p = 0.008
Total hippocampal volume	Preserved	p = 0.023
Global cerebrum volume	Preserved	p = 0.032
Full-Scale IQ	Improved	p = 0.039
Digit Span	Improved	p < 0.001

Interpretation: DHA supplementation at 2g/day for 12 months significantly slowed hippocampal atrophy and improved cognitive function in MCI patients.

DHA Brain Delivery (CSF Penetration)

Arellanes et al. (2020) — eBioMedicine:

33 cognitively unimpaired adults
2,152mg DHA/day for 6 months
Lumbar puncture before and after

Outcome	Change	P-value
CSF DHA	+28%	p < 0.0001
CSF EPA	+43%	p < 0.0001

APOE4 Effect: Non-APOE4 carriers had 3× greater CSF EPA increase than APOE4 carriers, suggesting APOE4 carriers may need higher doses.

Meta-Analysis: Dose-Response Relationship

2025 Meta-Analysis (Scientific Reports):

58 RCTs included
Dose-response analysis per 2000mg/day omega-3

Cognitive Domain	SMD per 2g/day	95% CI	GRADE
Attention	0.98	0.41–1.54	Low
Perceptual speed	0.50	0.05–0.95	Moderate
Language	0.37	0.12–0.62	Moderate

Conclusion: Higher omega-3 doses (≥2g/day) show dose-dependent cognitive benefits.

Stage-Dependent Effects

Clinical evidence consistently shows DHA is most effective when initiated before significant cognitive decline:

Population	DHA Efficacy	Interpretation
Healthy adults	Positive (memory, RT)	Prevention potential
Mild cognitive impairment	Positive (multiple domains)	Early intervention effective
Early Alzheimer’s (MMSE >27)	Positive	Narrow therapeutic window
Moderate-severe Alzheimer’s	Negative	Too late; damage irreversible

APOE Genotype Considerations

APOE4 carriers show altered DHA metabolism:

Less efficient DHA delivery to brain
Lower CSF DHA increase after supplementation
May require higher doses for equivalent brain effects
Shorter DHA half-life in plasma

Clinical Implication: APOE4 carriers may benefit from higher DHA doses or longer supplementation periods.

Synergies

DHA + Phosphatidylserine (Synergistic PS Expansion)

DHA and exogenous PS work through complementary mechanisms:NTRPX Synergy: ASG Boost contains both DHA (400mg) and Phosphatidylserine (100mg), providing dual-pathway PS optimization.

DHA + Choline + Uridine (Kennedy Cycle)

The “Kennedy Cycle” for phosphatidylcholine synthesis is enhanced by DHA:MIT Research (Wurtman Lab): Combined DHA + choline + uridine supplementation increases hippocampal synapses by 30%+ in animal models.NTRPX Implementation:

DHA from AvailOm® High DHA
Choline from CDP-Choline (Citicoline)
Uridine provided by CDP-Choline breakdown

DHA + Vitamin D3 + K2 (Fat-Soluble Triad)

Synergy Logic:

DHA provides optimal membrane environment for vitamin D receptor function
Vitamin D regulates serotonin synthesis — DHA enhances serotonin receptor function
K2 activates Gas6 (neuroprotective) — requires proper membrane integration
AvailOm® oil matrix enhances absorption of fat-soluble vitamins

DHA + EPA (Complementary Omega-3s)

Omega-3	Primary Role	Brain Fate	NTRPX Timing
DHA	Structural (membrane)	Incorporated into phospholipids	AM (Boost)
EPA	Signaling (anti-inflammatory)	Rapidly metabolized to SPMs	PM (Recover)

NTRPX Strategy: DHA-predominant in morning products (structural foundation), EPA-predominant in evening products (inflammation resolution during sleep).

DHA + Magnesium

Magnesium Role	DHA Interaction
Enzyme cofactor	Required for fatty acid metabolism enzymes
Membrane stability	Both modulate membrane fluidity
GABA function	Both support GABAergic signaling
Anti-inflammatory	Complementary pathways

Dosing Strategy

NTRPX DHA Distribution

Product	DHA Dose	EPA Dose	Total ω-3	Timing Rationale
ASG Boost™	400mg	300mg	700mg	Morning structural foundation
ASG Sustain™	200mg	100mg	300mg	Afternoon maintenance
ASG Recover™	100mg	300mg	400mg	Evening EPA-dominant recovery
Daily Total	700mg	700mg	1,400mg	Comprehensive coverage

Effective Dose Equivalency

AvailOm® bioavailability advantage means lower doses achieve equivalent plasma levels:

AvailOm® Dose	Equivalent Ethyl Ester Dose	Equivalent TG Dose
100mg DHA	500-900mg DHA (EE)	140-160mg DHA (TG)
400mg DHA	2,000-3,600mg DHA (EE)	560-640mg DHA (TG)
700mg DHA (daily)	3,500-6,300mg DHA (EE)	980-1,120mg DHA (TG)

Implication: NTRPX’s 700mg DHA from AvailOm® delivers the equivalent brain exposure of 3,500-6,300mg from standard fish oil softgels.

Evidence-Based Dosing by Indication

Indication	DHA Dose	Duration	Evidence Level
General brain health	250-500mg	Ongoing	Strong
Cognitive optimization	500-1,000mg	Ongoing	Moderate-Strong
MCI intervention	1,000-2,000mg	12+ months	Strong
Pregnancy/lactation	200-600mg	Gestation + nursing	Strong (critical)
Cardiovascular	500-1,000mg	Ongoing	Strong

Timing Considerations

Timing	Rationale	NTRPX Implementation
With food	Enhanced absorption (though AvailOm® less food-dependent)	Recommended with meals
Morning emphasis	DHA structural role; cognitive priming	Boost (400mg DHA)
Split dosing	Maintains more stable plasma levels	Boost + Sustain
Evening EPA	Resolution during sleep/recovery	Recover (EPA-dominant)

Population-Specific Dosing

Population	DHA Consideration	NTRPX Guidance
Healthy adults	500-700mg/day adequate	Standard protocol
APOE4 carriers	May need higher doses	Consider adding fatty fish 2×/week
Elderly (65+)	Higher baseline need	Standard protocol appropriate
Pregnancy	Critical for fetal brain	Consult physician; DHA essential
Vegetarian/vegan	Algal DHA option	AvailOm® is fish-derived; algal alternatives exist

Whole Foods Sources

Omega-3 Content of Common Foods

Food Source	Serving	DHA (mg)	EPA (mg)	Total ω-3 (mg)
Atlantic Salmon (wild)	3 oz (85g)	1,240	590	1,830
Atlantic Salmon (farmed)	3 oz (85g)	1,090	590	1,680
Atlantic Mackerel	3 oz (85g)	1,400	500	4,580*
Sardines (canned)	3 oz (85g)	740	450	1,190
Herring	3 oz (85g)	940	770	1,710
Anchovies	3 oz (85g)	870	760	1,630
Rainbow Trout (farmed)	3 oz (85g)	500	400	900
Albacore Tuna	3 oz (85g)	530	200	730
Oysters (raw)	6 medium	200	260	460
Cod	3 oz (85g)	130	50	180

*Mackerel includes additional omega-3s beyond EPA+DHA

Food Equivalents for NTRPX Daily DHA

To match NTRPX’s 700mg DHA from AvailOm® (accounting for 5-9× bioavailability = 3,500-6,300mg equivalent):

Food Source	Amount Needed Daily	Practical?	Notes
Wild Salmon	10-18 oz (280-510g)	✗ Impractical	Cost: $15-30/day
Canned Sardines	15-27 oz (425-765g)	✗ Impractical	4-7 cans/day
Mackerel	7-13 oz (200-370g)	⚠️ Challenging	Mercury consideration
Herring	12-21 oz (340-595g)	✗ Impractical	Rare in Western diet

Reality Check: Achieving equivalent DHA brain exposure through food alone is extremely difficult due to:

Standard fish oil absorption is 5-9× lower than AvailOm®
Cost of high-quality fatty fish
Practical consumption limits
Mercury exposure with large fish
Preparation time

Dietary Strategy for NTRPX Users

Optimized Approach: Use NTRPX omega-3s as reliable baseline; add whole food sources for additional benefits:

Weekly Target	Rationale	Foods
2-3 fatty fish servings	Provides matrix of nutrients beyond DHA	Salmon, sardines, mackerel
Seafood variety	Additional minerals (zinc, selenium, iodine)	Oysters, mussels, shrimp
Low-mercury choices	Safety	Sardines, anchovies, herring

Why Not Plant Sources?

Source	Omega-3 Type	Conversion to DHA	Practical DHA
Flaxseed	ALA	<0.5% conversion	Negligible
Chia seeds	ALA	<0.5% conversion	Negligible
Walnuts	ALA	<0.5% conversion	Negligible
Hemp seeds	ALA	<0.5% conversion	Negligible

Conversion Problem: Humans convert ALA → EPA → DHA extremely inefficiently:

ALA → EPA: ~5-10%
ALA → DHA: <0.5%

Plant sources cannot meaningfully contribute to DHA status. Direct DHA from marine sources (fish, algae) is required.

Cost Comparison

Source	Daily Cost for Equivalent DHA
Wild salmon (6+ oz/day)	$15-25
Quality fish oil softgels (8-12 caps)	$2-4
NTRPX (AvailOm® DHA)	Included in system
AvailOm® (standalone)	~$1-2

Value Proposition: AvailOm® provides superior bioavailability at a fraction of whole food cost, without mercury concerns or preparation requirements.

Safety & Classification

Adverse Event Profile

Event	Incidence	Severity	Notes
Fishy aftertaste	Rare with AvailOm®	Minimal	Lysine complex prevents
GI upset	Uncommon	Mild	Less than ethyl esters
Loose stools	Rare	Mild	High doses only
Prolonged bleeding time	Theoretical	N/A	Only at very high doses

At NTRPX doses (700mg DHA/day), adverse events are uncommon and mild.

Safety Data

Parameter	Finding	Source
Human clinical (up to 3g/day)	No serious adverse events	Multiple RCTs
FDA GRAS	Up to 3g/day EPA+DHA	FDA
EFSA	Up to 5g/day EPA+DHA	EFSA 2012
Oxidation markers	No increase at clinical doses	Multiple studies
LDL cholesterol	Modest increase possible at high doses	Monitor if concerned
AvailOm® stability	>4 years, low oxidation	Evonik data

Regulatory Status

Region	Status	Notes
United States	GRAS; dietary supplement	NDI registered
European Union	Novel Food approved	AvailOm® specifically
Japan	Food ingredient	Long history
Canada	NHP eligible	Licensed products

Drug Interactions

Drug Class	Interaction	Severity	Recommendation
Anticoagulants (warfarin)	Additive bleeding risk	★★★☆☆	Monitor INR
Antiplatelet (aspirin, clopidogrel)	Additive effect	★★☆☆☆	Generally safe; monitor
Antihypertensives	Additive BP lowering	★☆☆☆☆	May allow dose reduction
Statins	Complementary	★☆☆☆☆	Beneficial combination

Contraindications

Category	Consideration	Severity
Fish/shellfish allergy	Use algal DHA alternative	★★★★★ Absolute
Scheduled surgery	Stop 1-2 weeks before	★★★☆☆ Temporary
Active bleeding	Avoid until resolved	★★★★☆ Temporary

Special Populations

Population	Safety Status	Notes
Healthy adults	Excellent	Well-tolerated
Pregnancy	Essential	DHA critical for fetal brain; 200-600mg recommended
Lactation	Essential	DHA transfers to breast milk
Children	Excellent	Age-appropriate dosing
Elderly	Excellent	May have higher requirements
APOE4 carriers	Safe	May need higher doses for effect

Tier 1: Foundation

Efficacy

High — Essential structural nutrient

Validation

Strong — Extensive RCTs, mechanism elucidated

Safety

Excellent — GRAS, essential nutrient, long history

Tier Rationale: Tier 1 (Foundation) classification. DHA is not optional — it’s essential for brain structure, comprising 50% of neuronal membrane weight. Unlike most supplements that modulate function, DHA is literally structural. The brain cannot be built or maintained without it. Depletion causes measurable deficits in PS content, Akt signaling, and cognitive function. Human clinical trials demonstrate benefits for memory, hippocampal volume preservation, and cognitive function across multiple populations. The mechanism is definitively established: membrane architecture, PS synthesis, SPM production, and BDNF modulation. AvailOm® technology provides 5-9× superior bioavailability over standard supplements, ensuring actual brain delivery. Safety is excellent — DHA is an essential nutrient with GRAS status and extensive human data, including in pregnancy where it’s actively recommended.

Practical Considerations

When to Use DHA

Scenario	Expected Benefit	Protocol
Cognitive optimization	High	400-700mg daily, ongoing
Memory support	High	500-1000mg daily, 6+ months
MCI intervention	High	1000-2000mg daily, 12+ months
Pregnancy/nursing	Critical	200-600mg daily, entire period
Cardiovascular	High	500-1000mg daily, ongoing
General wellness	Moderate-High	250-500mg daily, ongoing

Realistic Expectations

Timeframe	What to Expect
Week 1-2	Plasma DHA rising; minimal subjective effects
Week 4-8	RBC membrane composition changing
Month 3	Brain DHA increasing; subtle cognitive effects
Month 6+	Measurable cognitive and structural benefits
Ongoing	Maintained brain architecture; prevention effects

Key Insight: DHA is a structural intervention. Unlike acute-acting compounds, DHA slowly incorporates into membrane phospholipids. Full effects require months of consistent supplementation.

Signs It’s Working

Indicator	Description
↑ Mental clarity	Improved focus and processing
↑ Memory	Better recall, especially episodic
↓ Brain fog	Reduced cognitive fatigue
Mood stability	More even emotional state
Visual function	Potentially improved (DHA in retina)

Optimizing Response

Strategy	Rationale
Take with meals	Enhanced absorption (less critical with AvailOm®)
Consistent daily use	Membrane incorporation requires chronic dosing
Combine with PS	Dual-pathway PS optimization
Include choline	Kennedy Cycle synergy
Ensure vitamin D	Receptor function requires membrane fluidity
Add fatty fish	Whole food matrix benefits

Frequently Asked Questions

How is DHA different from fish oil?

DHA is the active molecule — one of the omega-3 fatty acids in fish oil. Standard fish oil contains a mix of omega-3s (typically 30% EPA+DHA), plus other fatty acids. NTRPX uses concentrated DHA in the highly bioavailable AvailOm® form, ensuring you get the specific brain-building fatty acid in optimal amounts without filler fats.

Why does it take months to feel effects?

DHA is a structural molecule — it physically incorporates into your neuronal membranes. This isn’t like caffeine (instant effect) or even adaptogens (weeks). Membrane remodeling takes time: DHA must be absorbed, transported to the brain, acylated into phospholipids, and distributed across billions of neurons. Full membrane saturation requires 3-6 months of consistent supplementation.

Can I get enough DHA from diet alone?

Theoretically yes, but practically difficult. You’d need to eat fatty fish (salmon, mackerel, sardines) almost daily. Most people eat fish 1-2× per week at best, providing ~100mg DHA daily — far below optimal. Factor in cost ($15-25/day for adequate salmon), mercury concerns, and convenience, and supplementation becomes the practical solution.

What about plant-based omega-3s (flax, chia)?

Plant sources provide ALA (alpha-linolenic acid), not DHA. Humans convert ALA to DHA at <0.5% efficiency. You cannot meaningfully raise brain DHA levels with flax or chia seeds. If avoiding fish, use algae-derived DHA supplements (the original DHA source that fish accumulate).

Is AvailOm® worth the premium over standard fish oil?

Absolutely. Standard ethyl ester fish oil has 5-9× lower bioavailability than AvailOm®. You’d need to take 5-9 standard capsules to match one AvailOm® dose. Factor in the superior stability (no refrigeration, 4+ year shelf life), absence of fishy burps, and predictable absorption regardless of meal fat content — AvailOm® is the superior technology.

Should APOE4 carriers take more DHA?

Possibly. Research shows APOE4 carriers have less efficient DHA brain delivery and lower CSF DHA increases after supplementation. While the standard NTRPX dose provides excellent coverage, APOE4 carriers may benefit from additional fatty fish consumption or considering the upper end of dosing ranges. Discuss with a physician if you know your APOE status.

Can pregnant women take NTRPX DHA?

DHA is essential during pregnancy — it’s critical for fetal brain and eye development. International guidelines recommend 200-600mg DHA daily during pregnancy and lactation. However, pregnant women should consult their physician before taking any supplements, including NTRPX products.

Does DHA help with depression?

The omega-3 with strongest antidepressant evidence is EPA, not DHA. DHA supports brain structure and serotonin receptor function, but EPA more directly modulates inflammatory pathways linked to depression. NTRPX provides both: DHA-predominant in Boost/Sustain for structure, EPA-predominant in Recover for mood/inflammation.

NeuroStructure Summary: DHA (Docosahexaenoic Acid) at 700mg daily via AvailOm® High DHA is the structural foundation of cognitive architecture — comprising 50% of neuronal membrane weight and uniquely driving phosphatidylserine synthesis for Akt survival signaling. With 5-9× superior bioavailability over standard fish oil, AvailOm® ensures actual brain delivery of this essential fatty acid. Human clinical trials demonstrate preservation of hippocampal volume, improved memory, and cognitive benefits across multiple populations. DHA also serves as the precursor to Neuroprotectin D1 and other specialized pro-resolving mediators that terminate neuroinflammation. In NTRPX ASG Boost and Sustain, NeuroStructure DHA delivers the molecular foundation your neurons are literally built from.

Version: 1.0 | Last Updated: January 23, 2026 | Document Status: Complete Clinical MonographThis monograph establishes the DHA framework for NTRPX Systems. AvailOm® High DHA has been selected as the gold-standard delivery form based on superior bioavailability (5-9× vs ethyl esters), stability (>4 years), and clinical validation. Doses and product placements are optimized for synergy with phosphatidylserine, choline, and other NTRPX ingredients.

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